Results 141 to 150 of about 51,719 (196)

Extended-spectrum β-lactamase-producing Escherichia coli with chromosomally integrated resistance genes isolated from a wild Asian black bear. [PDF]

J Vet Med Sci
Sugiyama M, Morimoto T, Asai T.
europepmc   +1 more source

Artificial Intelligence-Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae. [PDF]

Adv Sci (Weinh)
Fitch JS, Ariadi MD, Kwun MJ, Howells L, Hernandez-Hernandez S, Croucher NJ, Ballester PJ.   +6 more
europepmc   +1 more source

Inhibitory effects of cefotaxime on the activity of mushroom tyrosinase [PDF]

Journal of Bioscience and Bioengineering, 2016
Tyrosinase (EC 1.14.18.1) catalyzes both the hydroxylation of tyrosine into o-diphenols and the oxidation of o-diphenols into o-quinones that form brown or black pigments.
Yong-Hua Hu, Qingxi Chen, Jiang-Xing Zhuang   +2 more
exaly   +2 more sources

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CEFOTAXIME AND NEPHROTOXICITY

The Lancet, 1979
info:eu-repo/semantics ...
Clumeck, Nathan, Vanhoof, Raymond, Vanlaethem, Yves, Butzler, Jean-Paul   +3 more
openaire   +3 more sources

Pharmacokinetics of cefotaxime and desacetyl-cefotaxime in neonates

Journal of Antimicrobial Chemotherapy, 1984
Cefotaxime was given to neonates as treatment of infection in a dose of 25 mg/kg 12 hourly by intravenous injection. Blood samples taken by heel-prick were specially treated to minimize any effect of haemolysis on the hydrolysis of cefotaxime. The mean peak plasma concentrations of cefotaxime on the first, second and third days of therapy were 43, 40 ...
J, Crooks, L O, White, L J, Burville, B D, Speidel, D S, Reeves   +4 more
openaire   +2 more sources

The action of  -lactamases on desacetyl-cefotaxime and cefotaxime

Journal of Antimicrobial Chemotherapy, 1984
Desacetyl-cefotaxime is the main cefotaxime metabolite. Its antibacterial activity is less than that of the parent molecule, but the combination of cefotaxime and desacetyl-cefotaxime is often synergistic. We analysed the hydrolysis of desacetyl-cefotaxime, in comparison with cefotaxime, by 10 beta-lactamases, mostly cephalosporinases, isolated from ...
R, Labia, A, Morand, A, Kazmierczak
openaire   +2 more sources

Pharmacokinetics of Cefotaxime and Desacetyl-Cefotaxime in Cirrhosis of the Liver

Chemotherapy, 2009
In 9 patients with advanced hepatic cirrhosis and a normal serum creatinine concentration, the pharmacokinetics of cefotaxime (CTX) and its desacetyl metabolite (DACM) were examined in serum and urine after intravenous administration of 2.0 g CTX. The peak serum levels were 130.3 ± 33.9 and 8.5 ± 4.6 mg/l for CTX and DACM, respectively.
G, Höffken, H, Lode, P, Koeppe, M, Ruhnke, K, Borner   +4 more
openaire   +2 more sources

Cefotaxime and desacetyl cefotaxime kinetics in renal impairment

Clinical Pharmacology and Therapeutics, 1985
Cefotaxime and desacetyl cefotaxime kinetics after a single, 1 gm intravenous dose were evaluated in five groups of subjects: group I, normal creatinine clearance (CLCR greater than 90 ml/min); group II, mild renal insufficiency (CLCR 30 to 89 ml/min); group III, moderate renal insufficiency (CLCR 16 to 29 ml/min); group IV, severe renal insufficiency (
G R, Matzke, P A, Abraham, C E, Halstenson, W F, Keane   +3 more
openaire   +2 more sources