Failure of ceftolozane‐tazobactam salvage therapy in complicated pneumonia with lung abscess
Key Clinical Message Treatment of Pseudomonas aeruginosa remains challenging, despite the availability ceftolozane‐tazobactam. We report a treatment failure with ceftolozane‐tazobactam salvage therapy for pneumonia complicated by lung abscess.
Paul O. Lewis +4 more
doaj +1 more source
Background A challenge in the empiric treatment of complicated urinary tract infection (cUTI) is identifying the initial appropriate antibiotic therapy (IAAT), which is associated with reduced length of stay and mortality compared with initial ...
Teresa L Kauf +7 more
doaj +1 more source
Extended-spectrum beta-lactamase-producing enterobacteriaceae : epidemiology and dynamics of fecal carriage [PDF]
ESBL-producing Enterobacteriaceae (EPE) has become a major cause of community acquired urinary tract infection (UTI), and fecal carriage of EPE is emerging worldwide.
Titelman, Emilia
core +1 more source
Clinical Characteristics, Microbiology and Outcomes of a Cohort of Patients Treated with Ceftolozane/Tazobactam in Acute Care Inpatient Facilities, Houston, Texas, USA [PDF]
BACKGROUND: Ceftolozane/tazobactam is a β-lactam/β-lactamase inhibitor combination with activity against a variety of Gram-negative bacteria, including MDR METHODS: We conducted a multicentre retrospective study of patients receiving at least 48 h of ...
Aitken, Samuel L +19 more
core +5 more sources
Background: Complicated urinary tract infection (cUTI) is often associated with drug-resistant pathogens and requires therapy with broad-spectrum antibiotics.
Guan-Jhou Chen +5 more
doaj +1 more source
The continued value of disk diffusion for assessing antimicrobial susceptibility in clinical laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group [PDF]
Expedited pathways to antimicrobial agent approval by the U.S. Food and Drug Administration (FDA) have led to increased delays between drug approval and the availability of FDA-cleared antimicrobial susceptibility testing (AST) devices.
Burnham, Carey-Ann D +6 more
core +2 more sources
Objective: This study compared the activity of ceftolozane–tazobactam and ceftazidime–avibactam against 120 bacterial strains, including extended-spectrum beta-lactamase (ESBL) producers, carbapenem-resistant Enterobacteriaceae (CRE), and Pseudomonas ...
Adnan Alatoom +9 more
doaj +1 more source
Potential of high-dose cefepime/tazobactam against multi-resistant Gram-negative pathogens [PDF]
Background: Early β-lactamase inhibitors were combined with established penicillins, but different combinations may be more appropriate to counter current β-lactamase threats, with development facilitated by the US Generating Antibiotic Incentives Now ...
Livermore, David M +4 more
core +1 more source
Background: Gram-negative rods are one of the most commonly isolated bacteria within human infections. These microorganisms are typically opportunistic pathogens that pose a serious threat to public health due to the possibility of transmission in the ...
Alicja Sękowska +2 more
doaj +1 more source
Treatment of infections caused by multidrug-resistant Gram-negative bacteria:Report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party [PDF]
The Working Party makes more than 100 tabulated recommendations in antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB) and suggest further research, and algorithms for hospital and ...
Enoch, David A +6 more
core +1 more source

