Results 121 to 130 of about 53,232 (282)
Journal of Health Economics and Outcomes Research, 2013 **Background:** Cyclooxygenase-2 inhibitors such as celecoxib are as effective as non-selective non-steroidal anti-inflammatory drugs (ns-NSAIDs) in the treatment of osteoarthritis (OA), have fewer gastrointestinal side effects, but are more expensive. *
Nadir Hammoumraoui +3 more
doaj
Cellular Physiology and Biochemistry, 2017 Background/Aims: The goal of this study was to detect the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinal pigmented epithelial (RPE) cells treated with celecoxib, a selective ...
Yi-zhou Sun, Na Cai, Ning-ning Liu
doaj +1 more source
Mol-AIR: Molecular Reinforcement Learning with Adaptive Intrinsic Rewards for Goal-directed Molecular Generation [PDF]
arXivOptimizing techniques for discovering molecular structures with desired properties is crucial in artificial intelligence(AI)-based drug discovery. Combining deep generative models with reinforcement learning has emerged as an effective strategy for generating molecules with specific properties.
arxiv
The use of topical diclofenac in the pain management of osteoarthritis of the knee [PDF]
, 2006 Osteoarthritis (OA) is a common complaint that affects millions of people worldwide. As there is no cure for OA, drug treatment is the main form of management.
Banning, M
core
Freispruch für Celecoxib [PDF]
MMW - Fortschritte der Medizin, 2016 Mehr als zehn Jahre nach dem sog. Vioxx®-Skandal spricht eine grose prospektive randomisierte Studie den COX-2-Inhibitor Celecoxib vom Verdacht auf kardiovaskulare Schadwirkungen frei. Doch die Studie weist Limitationen auf.
openaire +2 more sources
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Cancer Communications, Volume 45, Issue 5, Page 577-607, May 2025.Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan +13 more
wiley +1 more source
Gut Microbiota and Hepatocellular Carcinoma: Metabolic Products and Immunotherapy Modulation
Cancer Medicine, Volume 14, Issue 9, May 2025.ABSTRACT Background The relationship between hepatocellular carcinoma (HCC) and gut microbiota has gained attention for its impact on HCC immunotherapy. Methods Key gut microbial metabolites, including bile acids, toll‐like receptor 4, short‐chain fatty acids, and bacterial toxins, contribute to HCC progression and influence immune responses through ...
Kunmin Xiao +4 more
wiley +1 more source
Evaluation of health-related quality of life of rheumatoid arthritis patients treated with celecoxib [PDF]
, 2000 Sean Z. Zhao +6 more
openalex +1 more source
Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background Reactive oxygen species (ROS), a class of highly reactive molecules, are closely linked to the pathogenesis of various cancers. While ROS primarily originate from normal cellular processes, external stimuli can also contribute to their production. Cancer cells typically exhibit elevated ROS levels due to disrupted redox homeostasis,
Iqra Attique +6 more
wiley +1 more source
The celecoxib long-term safety study (CLASS): celecoxib is associated with less renal toxicity compared to conventional NSAIDs [PDF]
, 2000 A. Whalton
openalex +1 more source