Results 131 to 140 of about 66,137 (309)

A Systematic Review of Immune Cell Roles in Breast Cancer Immunotherapy

Cancer Reports, Volume 8, Issue 5, May 2025.
ABSTRACT Background Breast cancer (BC) is the most prevalent malignancy among women and is associated with high mortality and significant clinical challenges. Although conventional treatments such as surgery, chemotherapy, and radiotherapy have significantly improved patient survival, their efficacy remains limited by severe side effects and treatment ...
Rui Li, Wei Lv, Dong Liang Wang, Na Chen
wiley   +1 more source

Repurposing celecoxib as a topical antimicrobial agent

Frontiers in Microbiology, 2015
There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue.
Mohamed N. Seleem, Shankar eThangamani, Waleed ewyounis@purdue.edu   +2 more
doaj   +1 more source

Characterizing Treatment Effect Heterogeneity Using Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 117, Issue 5, Page 1209-1216, May 2025.
Characterizing heterogeneity of treatment effects (HTE) is a fundamental goal of pharmacoepidemiology, addressing why medications work differently across patient populations. This paper reviews state‐of‐the‐art methods for studying HTE using real‐world data (RWD), which offer larger study sizes and more diverse patient populations compared to ...
Haedi Thelen, Sean Hennessy
wiley   +1 more source

Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway

Cancer Cell International, 2017
COX-2, an inducible enzyme, is associated with inflammatory diseases and carcinogenesis. Overexpression of COX-2 occurs in many human malignancies, including osteosarcoma.
Bing Liu, Shigui Yan, Liyan Qu, Jian Zhu
semanticscholar   +1 more source

Nutraceutical Potential of Anthocyanins: A Comprehensive Treatise

Food Science &Nutrition, Volume 13, Issue 5, May 2025.
Anthocyanins reduce LDL, VLDL, TGs, and TC via improved GBA and upregulation of ATP6 V0C, ZO‐1, and ATG4D expression. The WHO/FAO suggested that 2.5 mg/kg/day of grape‐skin extracts of anthocyanins is safe, and China recommended that 50 mg/day of anthocyanins is safe for consumption.
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Muhammad Maaz, Aimen Mazhar, Naima Tariq, Muhammad Imran, Muzzamal Hussain, Ahmed Mujtaba, Mohamed A. Abdelgawad, Ehab M. Mostafa, Mohammed M. Ghoneim, Samy Selim, Entessar Al Jbawi   +12 more
wiley   +1 more source

Use of gastroprotective agents in recommended doses in hospitalized patients receiving NSAIDs: a drug utilization study [PDF]

, 2006
OBJECTIVE: In recent years, studies investigated to what extend recommendations for co-prescribing gastroprotective agents in prevention of NSAID-induced gastrointestinal complications are followed in clinical practice.
Bilušić, Marinko, Erdeljić, Viktorija, Francetić, Igor, Huić, Mirjana, Macolić Šarinić, Viola, Makar-Aušperger, Ksenija, Merčep, Iveta   +6 more
core   +1 more source

Mefloquine Suppresses Metastasis in Renal Cell Carcinoma Through Targeting SPC25

Cancer Science, Volume 116, Issue 5, Page 1239-1254, May 2025.
We addressed the clinical issue of renal cell carcinoma metastasis by identifying SPC25 protein as a research target through bioinformatics techniques and validation with clinical samples. We comprehensively validated the function of SPC25 protein and determined its impact on renal cancer.
Yongbo Wang, He Wang, Yipeng Xu, Jiawei Ling, Chuhong Zong, Yan Zhang, Xiaoxuan Guo, Guanan Zhao, Yuan Zhou, Jiahui Zhao, Pengrong Lou, Xigao Liu, Tengfei Xu, Qi Ma   +13 more
wiley   +1 more source

Synthesis Methods and Therapeutic Journey of Carprofen and Its Derivatives: A Review

Chemical Biology &Drug Design, Volume 105, Issue 5, May 2025.
Although it is currently only used in veterinary therapy, carprofen proves to be a molecule with a versatile therapeutic potential for human pharmacotherapy. Moreover, the molecule is a target in the drug discovery process for the development of new bioactive compounds.
Carmen Limban, Diana Camelia Nuță, Miron Teodor Caproiu, Denisa Elena Dumitrescu, Șerban Iancu Papacocea, Alexandra Teodora Bordei, Florea Dumitrașcu   +6 more
wiley   +1 more source

Celecoxib enhances the therapeutic efficacy of epirubicin for Novikoff hepatoma in rats

Cancer Medicine, 2018
Epirubicin is a chemotherapy agent for hepatocellular carcinoma (HCC). However, the outcome of HCC patients receiving epirubicin remains unsatisfactory.
Tian-Huei Chu, H. Chan, Tsung‐Hui Hu, E. Wang, Yi-Ling Ma, Shih-Chung Huang, Jian‐Ching Wu, Yi‐Chen Chang, Wen-Tsan Weng, Z. Wen, Deng-Chyang Wu, Y. Chen, M. Tai   +12 more
semanticscholar   +1 more source

Celecoxib Down-Regulates the Hypoxia-Induced Expression of HIF-1α and VEGF Through the PI3K/AKT Pathway in Retinal Pigment Epithelial Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: The goal of this study was to detect the expression of hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) in human retinal pigmented epithelial (RPE) cells treated with celecoxib, a selective ...
Yi-zhou Sun, Na Cai, Ning-ning  Liu
doaj   +1 more source