Results 181 to 190 of about 4,735,099 (379)

Cell-Based Assays to Identify Modulators of Nrf2/ARE Pathway. [PDF]

Methods Mol Biol, 2022
Wei Z, Zhao J, Zhang L, Xia M.
europepmc   +1 more source

An indicator cell assay for blood-based diagnostics

, 2017
Samuel A. Danziger, Leslie R. Miller, Karanbir Singh, G. Adam Whitney, Elaine R. Peskind, Ge Li, Robert J. Lipshutz, John D. Aitchison, Jennifer J. Smith   +8 more
openalex   +2 more sources

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

How to improve the sensitivity and specificity of cell-based assays in detecting autoantibodies in neuroimmune diseases. [PDF]

Ann Transl Med, 2023
Gao F, Zhang Y, Lv J, Wang S, He X, Liu P, Cui W.   +6 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Protocol for in vitro co-culture, proliferation, and cell cycle analyses of patient-derived leukemia cells

STAR Protocols
Summary: Leukemia niche impacts quiescence; however, culturing patient-derived samples ex vivo is technically challenging. Here, we present a protocol for in vitro co-culture of patient-derived xenograft acute lymphoblastic leukemia (PDX-ALL) cells with ...
Jessica Parker, Sean Hockney, Carly Knill, David McDonald, Andrew Filby, Deepali Pal   +5 more
doaj   +1 more source

Cell-Based Assays to Identify ERR and ERR/PGC Modulators. [PDF]

Methods Mol Biol, 2022
Lynch C, Zhao J, Xia M.
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Cell-Based Assays for Smoothened Ubiquitination and Sumoylation. [PDF]

Methods Mol Biol, 2022
Han Y, Jiang J.
europepmc   +1 more source

Tools for the identification of bioactives impacting the metabolic syndrome: screening of a botanical extract library using subcutaneous and visceral human adipose-derived stem cell-based assays

, 2011
Benjamin M. Buehrer, David J. Duffin, Y. Reneé Lea-Currie, David Ribnicky, Ilya Raskin, Jacqueline M. Stephens, William T. Cefalu, Jeffrey M. Gimble   +7 more
openalex   +2 more sources