Results 161 to 170 of about 1,974,930 (309)

Utility of Live Cell-Based Assays for Autoimmune Neurology Diagnostics. [PDF]

J Appl Lab Med, 2022
Woodhall M, Mgbachi V, Fox H, Irani S, Waters P.   +4 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based Assays. [PDF]

Molecules, 2022
Hung HC, Li LC, Guh JH, Kung FL, Hsu LC.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Cutting edge strategies for screening of novel anti-HIV drug candidates against HIV infection: A concise overview of cell based assays. [PDF]

Heliyon, 2023
Gaikwad SY, Phatak P, Mukherjee A.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Prozone phenomenon in pretransplant testing: An interesting conundrum involving solid-phase and cell-based assays. [PDF]

Asian J Transfus Sci, 2022
Singh P, Tiwari AK, Mishra VC, Deshpande TV, Dorwal P, Bhardwaj AK, Kumari S, Raina V.   +7 more
europepmc   +1 more source

Antiretroviral effect of 4-thio-uridylate against human immunodeficiency virus type 1 [PDF]

, 2012
Albert J., Barbouche R., Beck Z., Berger E. A., Clapham P., Cox S., Doms R. W., Einfeld D., Fenouillet E., Horváth A., Horváth A., Joseph Ongrádi, Juhász E., Kanizsai S., Kanizsai Sz., Kemény B., Kilby J. M., Károly Nagy, Leonard C., Markovic I., Matthias L. J., Nagy K., Nagy K., Nagy K., Nisole S., Ou W., Ryser H. J., Szatmari I., Szilvia Kanizsai, Tarkanyi I., Tõkés S., Wittinghoff E., Ágoston Ghidán   +32 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Elucidating EGCG' s targets in nasopharyngeal carcinoma through combined cell-based assays and transcriptomic sequencing. [PDF]

Discov Oncol
Yang Y, Xuan G, Feng Z, Deng M, Liu F, Liu Q, Wang W, Li Z, Zuo D, Li Z, Wei C, Luo W, Li F, Ma N, He F, Murata M.   +15 more
europepmc   +1 more source