Results 231 to 240 of about 1,959,228 (334)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cell-based assays and comparative genomics revealed the conserved and hidden effects of Wolbachia on insect sex determination. [PDF]

PNAS Nexus
Arai H, Herran B, Sugimoto TN, Miyata M, Sasaki T, Kageyama D.   +5 more
europepmc   +1 more source

High-throughput mechanobiology: Force modulation of ensemble biochemical and cell-based assays. [PDF]

Biophys J, 2021
Dos Santos Á, Fili N, Pearson DS, Hari-Gupta Y, Toseland CP.   +4 more
europepmc   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Induced pluripotent stem cell-based assays recapture multiple properties of human astrocytes. [PDF]

J Cell Mol Med
Nonaka H, Kondo T, Suga M, Yamanaka R, Sagara Y, Tsukita K, Mitsutomi N, Homma K, Saito R, Miyoshi F, Ohzeki H, Okuyama M, Inoue H.   +12 more
europepmc   +1 more source

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes. [PDF]

SLAS Discov, 2022
Kassner M, Eaton JB, Tang N, Petit JL, Meurice N, Yin HH, Whiteaker P.   +6 more
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Exploiting Cell-Based Assays to Accelerate Drug Development for G Protein-Coupled Receptors. [PDF]

Int J Mol Sci
Wu Y, Jensen N, Rossner MJ, Wehr MC.
europepmc   +1 more source

Detection of MOG-IgG in Clinical Samples by Live Cell-Based Assays: Performance of Immunofluorescence Microscopy and Flow Cytometry. [PDF]

Front Immunol, 2021
Marchionatti A, Hansel G, Avila GU, Sato DK.   +3 more
europepmc   +1 more source

MOG cell-based assay detects non-MS patients with inflammatory neurologic disease [PDF]

, 2015
Patrick Waters, Mark Woodhall, Kevin C. O’Connor, Markus Reindl, Bethan Lang, Douglas Kazutoshi Sato, Maciej Juryńczyk, George Tackley, João Rocha, Toshiyuki Takahashi, Tatsuro Misu, Ichiro Nakashima, Jacqueline Palace, Kazuo Fujihara, Maria Isabel Leite, Angela Vincent   +15 more
openalex   +1 more source