Results 261 to 270 of about 1,974,930 (309)
Some of the next articles are maybe not open access.
Microchips for Cell-Based Assays
2009Analysis of cells is a cornerstone in biomedical research. Traditional methods for cell culture and tissue analysis can be replaced by various microchips as discussed in this chapter. A tissue array is an example of microchip that provides higher throughput of tissue analysis.
openaire +2 more sources
Cell-based assay for β-secretase activity
Analytical Biochemistry, 2003The cerebral deposition of amyloid beta-peptide (Abeta) is a major factor in the etiology of Alzheimer's disease. beta-Secretase (BACE) initiates the generation of Abeta by cleaving the amyloid precursor protein at the beta-site and is therefore a prime target for therapeutic intervention. Here we report a cell-based method suitable for monitoring BACE
Myungsok, Oh +6 more
openaire +2 more sources
Microarray Platforms for Enzymatic and Cell‐Based Assays
ChemInform, 2007AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Juan J, Díaz-Mochón +2 more
openaire +2 more sources
Analyzing Trophoblast Function Using Cell-Based Assays
2017Functional cell-based assays are useful for comparing the effect of a treatment, drug, or condition on cells in culture. Cell lines are a commonly used model to replicate a normal biological process or a pathological condition. Trophoblasts within the placenta are required to perform a variety of functions, which include proliferation, differentiation,
Katie L, Powell, Anthony W, Ashton
openaire +2 more sources
Contact hypersensitivity: T-cell based assay
Current Opinion in Toxicology, 2017Abstract To develop an in vitro assay that recapitulates the key event of Allergic Contact Dermatitis (ACD), that is the priming of human effector T cells by hapten-presenting dendritic cells (DCs), and then allows for the sensitive detection of chemical allergens, represents a highly desirable goal but also a major challenge.
Marc Vocanson +7 more
openaire +2 more sources
High-throughput cell-based assays in yeast
Drug Discovery Today, 2002With the sequencing of many genomes now completed, biologists are faced with the challenge of deciphering the function and association of an immense number of predicted proteins. Comprehension of the networks of proteins and chemicals that comprise the cells and tissues of an organism, and the specific roles of proteins in these networks, will be a ...
openaire +2 more sources
Cell‐based assays in GPCR drug discovery
Biotechnology Journal, 2008AbstractG protein‐coupled receptors (GPCRs) transmit extracellular signals into the intracellular space, and play key roles in the physiological regulation of virtually every cell and tissue. Characteristic for the GPCR superfamily of cell surface receptors are their seven transmembrane‐spanning α‐helices, an extracellular N terminus and intracellular ...
openaire +2 more sources
Cell Based Assays for Drug Screening
1997A CRE-alkaline Phosphatase reporter construct has been introduced into a mammalian cell line to investigate signal transduction pathways used by the calcitonin receptor. Calcitonin activated alkaline Phosphatase production in the CRE-reporter cell line.
Elizabeth Keenan +3 more
openaire +1 more source
Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
exaly