Results 31 to 40 of about 455 (206)

Plasma concentration of platelet-derived microparticles is related to painful vaso-occlusive phenotype severity in sickle cell anemia. [PDF]

PLoS ONE, 2014
High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting ...
Danitza Nebor, Andre Bowers, Philippe Connes, Marie-Dominique Hardy-Dessources, Jennifer Knight-Madden, Vanessa Cumming, Marvin Reid, Marc Romana   +7 more
doaj   +1 more source

Immune cell-derived microparticles in polymyositis/dermatomyositis [PDF]

Annals of the Rheumatic Diseases, 2010
Microparticles are recently recognised players of intercellular communication. They are involved in signal transduction, cell activation and apoptosis. Their importance is also suggested in autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. We investigated the role of microparticles in polymyositis/dermatomyositis, a group of rare
Z Baka, L Senolt, J Vencovsky, H Mann, P Sebestyén Simon, Á Kittel, E Buzás, G Nagy   +7 more
openaire   +1 more source

Mitigating the non-specific uptake of immunomagnetic microparticles enables the extraction of endothelium from human fat

Communications Biology, 2021
Antonyshyn et al. establish a methodology for acquiring human adipose tissue-derived microvascular endothelial cells that can be readily applied in future vascular tissue engineering applications.
Jeremy A. Antonyshyn, Vienna Mazzoli, Meghan J. McFadden, Anthony O. Gramolini, Stefan O. P. Hofer, Craig A. Simmons, J. Paul Santerre   +6 more
doaj   +1 more source

Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells.

PLoS ONE, 2012
Cell-derived microparticles participate in intercellular communication similar to the classical messenger systems of small and macro-molecules that bind to specialized membrane receptors. Microparticles have been implicated in the regulation of a variety
Panpan Chen, Steven D Douglas, John Meshki, Florin Tuluc   +3 more
doaj   +1 more source

Circulating microparticles are increased amongst people presenting with HIV and advanced immune suppression in Malawi and correlate closely with arterial stiffness: a nested case control study [version 2; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2022
Background: We aim to investigate whether circulating microparticle (CMPs) subsets were raised amongst people presenting with a new diagnosis of HIV and advanced immune suppression in Malawi, and whether they associated with arterial stiffness.
Christine Kelly, Raphael Kamng'ona, Rijan Gurung, Kondwani Jambo, Mishek Chammudzi, Irene Sheha, Rob Heyderman, Jane Mallewa, Henry Mwandumba, Patrick Mallon, Saye Khoo, Nigel Klein, Alicja Rapala   +12 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Freeze-Derived Anisotropic Porous Microparticles for Engineered Mesenchymal Stem Cell Loading and Wound Healing

Research
Hydrogel microparticles that can effectively deliver mesenchymal stem cells (MSCs) are expected to accelerate wound repair progress. Attempts in the area are focusing on improving the functions of the microparticles and MSCs to promote the therapeutic ...
Rongwei Cai, Shuangshuang Miao, Xinyue Cao, Min Nie, Yuanjin Zhao   +4 more
doaj   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Microparticle alpha‐2‐macroglobulin enhances pro‐resolving responses and promotes survival in sepsis

EMBO Molecular Medicine, 2013
Incorporation of locally produced signaling molecules into cell‐derived vesicles may serve as an endogenous mediator delivery system. We recently reported that levels alpha‐2‐macroglobulin (A2MG)‐containing microparticles are elevated in plasma from ...
Jesmond Dalli, Lucy V Norling, Trinidad Montero‐Melendez, Donata Federici Canova, Hazem Lashin, Anton M Pavlov, Gleb B Sukhorukov, Charles J Hinds, Mauro Perretti   +8 more
doaj   +1 more source

Mechanism of trophoblast cell‐derived microparticles mediated immunocontraceptive response

American Journal of Reproductive Immunology, 2023
AbstractProblemImmunomodulation profoundly affects the process of human implantation. Trophoblast cell‐derived microparticles (Tr‐MPs) may activate specific T cells to attack trophoblast cells, thus potentially acting as an immunocontraceptive vaccine.
Shao-Yang, Lai, Kai-Lun, Hu, Xuan, Zhou, Xiao-Xue, Li, Xiao-Jun, Yu, Jing, Shi, Jie, Zhao   +6 more
openaire   +2 more sources