Results 241 to 250 of about 5,340,670 (292)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

Designed Cell-Penetrating Peptide Constructs for Inhibition of Pathogenic Protein Self-Assembly. [PDF]

Pharmaceutics
Kalmouni M, Oh Y, Alata W, Magzoub M.
europepmc   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Cell-Penetrating Peptide Enhances Tafazzin Gene Therapy in Mouse Model of Barth Syndrome. [PDF]

Int J Mol Sci
Raghav R, Awata J, Martin GL, Strathdee D, Blanton RM, Chin MT.   +5 more
europepmc   +1 more source

Targeting <i>carA</i> Using Optimized Antisense Peptide Nucleic Acid-Cell-Penetrating Peptide Conjugates in <i>Acinetobacter baumannii</i>: A Novel Antibacterial Approach. [PDF]

Int J Mol Sci
Seo JH, Kim YJ, Jeon WJ, Yoo JS, Moon DC.   +4 more
europepmc   +1 more source

Coassembly of Cell-Penetrating Peptide Octaarginine with Acetazolamide: Emergent Interactions with E. coli. [PDF]

ACS Omega
Choubey R, Chatterjee M, Pandey PK, Mishra A, Datta B.   +4 more
europepmc   +1 more source

Cell-penetrating peptide-grafted AAV2 capsids for improved retinal delivery via intravitreal injection. [PDF]

Mol Ther Methods Clin Dev
Wang JH, Cui M, Liu H, Guo P, McGowan J, Cheng SY, Gessler DJ, Xie J, Punzo C, Tai PWL, Gao G.   +10 more
europepmc   +1 more source

A dual functional mucus- and cell-penetrating peptide enhances mRNA lipid nanoparticle delivery to the lung. [PDF]

Mol Ther Nucleic Acids
Kumar S, Duncan GA.
europepmc   +1 more source

Cell-Penetrating Peptides

, 2021
In this introductory chapter, we first define cell-penetrating peptides (CPPs), give short overview of CPP history and discuss several aspects of CPP classification. Next section is devoted to the mechanism of CPP penetration into the cells, where direct and endocytic internalization of CPP is explained.
Matjaž, Zorko, Ülo, Langel
openaire   +3 more sources