Results 301 to 310 of about 371,071 (337)

Cell-penetrating peptides

Trends in Pharmacological Sciences, 2000
The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren, M, Hällbrink, A, Prochiantz, U, Langel   +3 more
openaire   +2 more sources

Predicting cell-penetrating peptides

Advanced Drug Delivery Reviews, 2008
Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Mats, Hansen, Kalle, Kilk, Ulo, Langel
openaire   +2 more sources

Empirical comparison and analysis of web-based cell-penetrating peptide prediction tools

Briefings Bioinform., 2019
Cell-penetrating peptides (CPPs) facilitate the delivery of therapeutically relevant molecules, including DNA, proteins and oligonucleotides, into cells both in vitro and in vivo.
R. Su, Jie Hu, Q. Zou, Balachandran Manavalan, Leyi Wei   +4 more
semanticscholar   +1 more source

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT).

Chemical Communications, 2019
In this study, we designed and synthesized organelle-targeted cell-penetrating peptide (CPP)-conjugated boron compounds to increase their cellular uptake and to control the intracellular locations for the induction of sophisticated anticancer biological ...
I. Nakase, Miku Katayama, Yoshihide Hattori, Miki Ishimura, Shunsuke Inaura, Daisuke Fujiwara, Tomoka Takatani-Nakase, I. Fujii, S. Futaki, M. Kirihata   +9 more
semanticscholar   +1 more source

Cell‐Penetrating Peptide Foldamers: Drug‐Delivery Tools

ChemBioChem, 2019
Highly efficient drug‐delivery tools for membrane‐impermeable compounds, proteins, and nucleic acids in living cells are useful in the fields of chemical biology and drug discovery, and such tools have been widely studied. One strategy in the development
M. Oba
semanticscholar   +1 more source

Intracellulartransduction using cell-penetrating peptides

Mol. BioSyst., 2010
Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous examples illustrating the potential ...
Rupa, Sawant, Vladimir, Torchilin
openaire   +2 more sources

Prediction of Cell-Penetrating Peptides

2015
The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
openaire   +2 more sources

Proteomimetic Cell Penetrating Peptides

International Journal of Peptide Research and Therapeutics, 2008
QSAR analysis of the primary sequence of human cytochrome c indicated that numerous putative cell penetrating peptide sequences are located within major amino- and carboxyl-terminal helical domains. Two such sequences, Cyt c77−101 and the shorter homologue Cyt c86−101, readily translocate the plasma membrane of U373MG astrocytoma cells but ...
John Howl, Sarah Jones
openaire   +1 more source

Classes of Cell-Penetrating Peptides

2015
During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
openaire   +2 more sources

The Pharmacokinetics of Cell-Penetrating Peptides

Molecular Pharmaceutics, 2010
Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko, Barbro, Beijer, Regine, Garcia Boy, Eva-Maria, Nothelfer, Karin, Leotta, Michael, Eisenhut, Annette, Altmann, Uwe, Haberkorn, Walter, Mier   +8 more
openaire   +2 more sources