Results 311 to 320 of about 371,071 (337)
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Cell-penetrating Peptide-mediated Nanovaccine Delivery
Current Drug Targets, 2021Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to activate the immune system and trigger the protective immune responses against a pathogen. Currently, nanovaccines are undergoing development instead of conventional vaccines.
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pH-responsive PepFect cell-penetrating peptides
International Journal of Pharmaceutics, 2016A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to form non-covalent complexes with an oligonucleotide cargo by co-incubation in buffer.
Regberg +5 more
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Proline-rich, amphipathic cell-penetrating peptides
Advanced Drug Delivery Reviews, 2008Proline-rich peptides are a chemically and structurally diverse family of cell-penetrating vectors characterised by the presence of pyrrolidine rings from prolines. Amphipathic Pro-rich peptides are particularly effective, demonstrating efficient cellular uptake and non-cytotoxicity.
Sílvia, Pujals, Ernest, Giralt
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Cell Penetrating Peptides for Tumor Targeting
Current Pharmaceutical Biotechnology, 2011Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy.
Young Suk, Choi +6 more
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Therapeutic Potential of cell-penetrating Peptides
Therapeutic Delivery, 2013The ability of cell-penetrating peptides to cross plasma membranes has been used for various applications, including the delivery of bioactive molecules to inhibit disease-producing cellular mechanisms. Selective drug delivery into target cells improves drug distribution and decreases dosing and toxicity.
Luís, Vasconcelos +2 more
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Cell Penetrating Peptides in Drug Delivery
Pharmaceutical Research, 2004Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism.
Eric L, Snyder, Steven F, Dowdy
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Peptide–glycosaminoglycan cluster formation involving cell penetrating peptides
Biopolymers, 2011AbstractGlycosaminoglycans (GAGs) affect the efficiency of cellular uptake of a wide range of cell penetrating peptides (CPPs). GAGs have been proposed to cluster with CPPs at the cell surface before uptake but little is known about the formation or stability of CPP–GAG clusters.
Anthony, Rullo, Jieshu, Qian, Mark, Nitz
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Antibacterial cell-penetrating peptides
2021The present disclosure relates to novel antibacterial cell penetrating peptides and derivatives, and methods to make and use the novel antibacterial cell-penetrating peptides and derivatives. The novel antibacterial cell-penetrating peptides of the present invention with shorter linker between a pyrrolidine ring and a guanidine group provide ...
Chmielewski, Jean, Seleem, Mohamed N.
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Therapeutic Applications of Cell-Penetrating Peptides
2010Since the discovery over 15 years ago of a protein transcription factor that possessed the ability to cross the plasma membrane, cell-penetrating peptides (CPPs) have been evaluated for the ability to transport diverse cargoes into cells, tissues, and organs.
Randolph M, Johnson +2 more
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