Results 101 to 110 of about 5,601,044 (283)

Enzymatic activation of cell-penetrating peptides in self-assembled nanostructures triggers fibre-to-micelle morphological transition [PDF]

, 2017
Enzyme-assisted fibre-to-micelle transition in self-assembled nanostructures controls presentation of cell-penetrating peptides.
Yang Hu, Azevedo, HS, Lin, R, Cui, H, Yejiao Shi, Guy Ochbaum, Bitton, R, Ochbaum, G, Ran Lin, Hu, Y, Ronit Bitton, Honggang Cui, Helena S. Azevedo, Shi, Y   +13 more
core   +1 more source

Tailored Cationic Visible‐Light‐Active Interfaces for Sustainable, Biodegradable Nanofibers With Dual‐Mode Antimicrobial Activity and Robust Electrostatic Particle Capture

Advanced Materials, EarlyView.
Surface co‐functionalization of biodegradable nanofibers with sodium copper chlorophyllin and quaternary ammonium compounds achieves synergistic antimicrobial activity through combined photodynamic and contact‐killing mechanisms. The cationic surface provides humidity‐resistant electrostatic particle capture while maintaining rapid enzymatic ...
Dong Uk Lee, Jae Hak Shin, Seung Yeon Lee, In Ho Kim, Jiho Choi, Joon Young Park, Sang Bok Kim, Jeong Sang Son, Sang Hun Kim, Jae Hee Jung, Dong Yun Choi   +10 more
wiley   +1 more source

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

Nature Communications, 2017
In vitroblood-brain barrier (BBB) models are crucial tools for screening brain-penetrating compounds. Here the authors develop a self-assembling BBB spheroid model with superior performance to the standard transwell BBB model, and use their platform to ...
Choi-Fong Cho, Justin M. Wolfe, Colin M. Fadzen, David Calligaris, Kalvis Hornburg, E. Antonio Chiocca, Nathalie Y. R. Agar, Bradley L. Pentelute, Sean E. Lawler   +8 more
doaj   +1 more source

Cell-Penetrating Peptides Containing Fluorescent d -Cysteines

, 2018
A series of fluorescent d-cysteines (Cys) has been synthesized and their optical properties were studied. The key synthetic step is the highly diastereoselective 1,4-conjugate addition of aryl thiols to a chiral bicyclic dehydroalanine recently developed
Gonzalo Jiménez-Osés, Ezcurra, B. [0000-0001-7211-2616], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], Compañón, I., Gutiérrez-Jiménez, M.I., Eva Gómez-Orte, Jesús H. Busto, Jesús M. Peregrina, Begoña Ezcurra, Ismael Compañón, Zurbano, M.M. [0000-0001-6370-3537], Juan Cabello, Jiménez-Osés, G. [0000-0003-0105-4337], Asín, A., Alberto Avenoza, Francisco Corzana, Marta I. Gutiérrez-Jiménez, Corzana, F. [0000-0001-5597-8127], Cabello, J. [0000-0002-3835-0116], Peregrina, J.M. [0000-0003-3778-7065], Claudio D. Navo, María M. Zurbano, Navo, C.D. [0000-0003-0161-412X], Alicia Asín, Gómez-Orte, E. [0000-0001-6802-1746]   +25 more
core   +1 more source

A Critical Review on the Evolution of Chitosan‐Based Injectable Hydrogels in Bone Regeneration

Advanced Materials Interfaces, EarlyView.
The graphical illustration depicts hydrogel formulation using chitosan and biocompatible cross‐linkers, major advantages, and incorporation of cells, osteoinductive factors, and therapeutic drugs. Following injection, pH‐responsive gelation enables controlled drug release, promotes cell recruitment and osteogenic differentiation, enhances extracellular
Shivani Santosh Sakhrani, Abu ul Hassan S. Rana, S. Sudheer Khan   +2 more
wiley   +1 more source

The Uptake Mechanism of the Cell-Penetrating pVEC Peptide

Journal of Chemistry, 2013
Peptide based drug design efforts have gained renewed interest with the discovery of cargo-carrying or cell-penetrating peptides. Understanding the translocation mechanism of these peptides and identifying the residues or elements that contribute to ...
Ihsan Omur Akdag, Elif Ozkirimli
doaj   +1 more source

Cell-Penetrating Peptides Using Cyclic α,α-Disubstituted α‑Amino Acids with Basic Functional Groups

, 2018
In the delivery of cell-impermeable molecules, cell-penetrating peptides (CPPs) have been attracting increasing attention as intracellular delivery tools.
Takuma Kato (493431), Makoto Oba (338218), Koyo Nishida (1735597), Masakazu Tanaka (493432)   +3 more
core   +1 more source

Silk Fibroin Nanofiber–Immobilized Horseradish Peroxidase Enables Continuous Preparation of Injectable Hydrogels With Negligible Residual Enzyme for Drug Delivery

Advanced Materials Technologies, EarlyView.
Overcoming the immunogenicity challenges of enzyme‐mediated crosslinking, a flow‐through reactor utilizing SFNF‐HRP enables the continuous production of injectable hydrogels. This continuous platform ensures homogeneous crosslinking while minimizing residual HRP in the resulting hydrogels.
Ayari Miyawaki, Shinji Sakai
wiley   +1 more source

Extrusion‐Based Bioprinting of Living Bioinks for Tissue and Organ Engineering

Advanced Materials Technologies, EarlyView.
Extrusion‐based bioprinting is presented as the most versatile route for fabricating living, heterogeneous tissues. Its ability to combine diverse bioinks, support matrices, and advanced printhead geometries transforms familiar constraints into powerful biofabrication opportunities.
Eric Silberman, Ester Sapir Baruch, Roni Cohen, Assaf Shapira, Tal Dvir   +4 more
wiley   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source