Results 141 to 150 of about 395,472 (375)

Machine-Learning-Based Prediction of Cell-Penetrating Peptides and Their Uptake Efficiency with Improved Accuracy.

Journal of Proteome Research, 2018
Cell-penetrating peptides (CPPs) can enter cells as a variety of biologically active conjugates and have various biomedical applications. To offset the cost and effort of designing novel CPPs in laboratories, computational methods are necessitated to ...
Balachandran Manavalan, S. Subramaniyam, T. Shin, M. Kim, Gwang Lee   +4 more
semanticscholar   +1 more source

MPI‐Guided Photothermal Therapy of Prostate Cancer Using Stem Cell Delivery of Magnetotheranostic Nanoflowers

Advanced Functional Materials, EarlyView.
Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi, Ana Rosu, Shreyas Kuddannaya, Gautier Laurent, Rana Bazzi, Stéphane Roux, Ali Shakeri‐Zadeh, Jeff W. M. Bulte   +7 more
wiley   +1 more source

Astrocyte‐Guided Maturation of Neural Constructs in a Modular Biosynthetic Hydrogel for Biohybrid Neurotechnologies

Advanced Functional Materials, EarlyView.
A modular biosynthetic PVA–gelatin hydrogel crosslinked via visible‐light thiol‐ene chemistry is engineered as a coating for neural electrodes. Optimizing matrix composition and mechanical properties enables the hydrogel to support astrocytic populations that guide neural differentiation and functional maturation.
Martina Genta, Sofia Peressotti, Roberto Portillo‐Lara, Josef Goding, Rylie Green   +4 more
wiley   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Mitoparans: mitochondriotoxic cell penetrating peptides and novel inducers of apoptosis. [PDF]

, 2007
Acknowledgments The authors would like to thank Keith Holding at the University of Wolverhampton for his outstanding technical support. This work was supported in part by Samantha Dickson Brain Tumour Trust.Introduction: The amphipathic helical peptide ...
Belzacq-Casagrande, Anne-Sophie, Brenner, Catherine, Howl, John D., Jones, Sarah, Martel, Cecile   +4 more
core   +1 more source

Cell‐penetrating peptides: Achievements and challenges in application for cancer treatment [PDF]

, 2014
One of the major hurdles to cure cancer lies in the low potency of currently available drugs, which could eventually be solved by using more potent therapeutic macromolecules, such as proteins or genes.
Aderem, Agarwal, Balzeau, Brugidou, Calnan, Choi, Chopra, Christiaens, Conner, Crombez, Cryan, Derossi, Derossi, Dietz, Dodd, Drin, Dubikovskaya, Dupont, El-Andaloussi, Elmquist, Ezzat, Fawell, Fisher, Frankel, Fretz, Fuente, Fulda, Futaki, Gros, Hajdu, Hamilton, Han, Harris, Heitz, Hollstein, Hosotani, Hutmacher, Inoue, Jain, Jarver, Jiang, Jiang, Joliot, Josephson, Juliano, Juliano, Kale, Kaplan, Kaufman, Khalil, Kim, Kim, Kleemann, Koppelhus, Koren, Kuan, Kushner, Kwon, Kwon, Lee, Lewin, Liggett, Lindgren, Los, Lu, Ludtke, Mae, Maiolo, Marty, Matsuzaki, Meade, Mei, Michiue, Michl, Moon, Morris, Morris, Mortensen, Myrberg, Nakamura, Nan, Oehlke, Oehlke, Olson, Olson, Park, Park, Patel, Pooga, Pouny, Pridgen, Prochiantz, Prochiantz, Ratner, Richard, Roach, Rousselle, Rousselle, Roux, Rudolph, Sawant, Scheller, Schwarze, Schwarze, Sethuraman, Shokolenko, Snyder, Snyder, Snyder, Stirpe, Stroh, Suk, Tkachenko, Torchilin, Torchilin, Torchilin, Torchilin, Tseng, Tunnemann, Vives, Vucic, Wadia, Wender, Winer, Yagi, Zasloff, Zhang, Zhang, Zhao   +128 more
core   +1 more source

Cell-Penetrating Peptides: Efficient Vectors for Vaccine Delivery

Current Drug Delivery, 2019
Subunit vaccines are composed of pathogen fragments that, on their own, are generally poorly immunogenic. Therefore, the incorporation of an immunostimulating agent, e.g. adjuvant, into vaccine formulation is required.
Jieru Yang, Yacheng Luo, Mohini A Shibu, I. Toth, M. Skwarczynski   +4 more
semanticscholar   +1 more source

Real‐Time, Label‐Free Monitoring of Cell Behavior on a Bioelectronic Scaffold

Advanced Functional Materials, EarlyView.
A bioelectronic nanofibrous scaffold is introduced that supports cell growth while enabling real‐time, label‐free monitoring of cellular behavior through impedance measurements. The system correlates electrical signals with cell viability and surface coverage, offering an integrated platform for studying dynamic biological processes and advancing next ...
Dana Cohen‐Gerassi, Offir Loboda, Aakash Jog, Or Messer, Dor Aaron Goldstein, Tomer Reuveni, Moran Aviv, Amit Sitt, Yosi Shacham‐Diamand, Maxim Sokol, Lihi Adler‐Abramovich   +10 more
wiley   +1 more source

Arginine-rich cell-penetrating peptides induce membrane multilamellarity and subsequently enter via formation of a fusion pore

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The passive translocation mechanism of arginine-rich cell-penetrating peptides has puzzled the scientific community for more than 20 y. In this study we propose a hitherto unrecognized mechanism of passive cell entry involving fusion of ...
Christoph Allolio, A. Magarkar, P. Jurkiewicz, Katarína L. Baxová, M. Javanainen, P. Mason, Radek Šachl, M. Cebecauer, M. Hof, D. Horinek, Veronika Heinz, R. Rachel, C. Ziegler, A. Schröfel, P. Jungwirth   +14 more
semanticscholar   +1 more source

Engineering a Sonotherapeutic RBC Membrane‐Derived Nanoparticle Platform for the Treatment of Liver Cancer

Advanced Functional Materials, EarlyView.
Herein, an RBC membrane‐derived nanoparticle (CMN‐ICG) is engineered to efficiently deliver a sonosensitizing agent, indocyanine green (ICG), for sonotherapy of hepatocellular carcinoma (HCC). CMN‐ICG exhibits excellent cytocompatibility, significantly enhances hepatocyte uptake, and produces excessive reactive oxygen species (ROS) upon ultrasound ...
Alap Ali Zahid, Aishik Chakraborty, Wei Luo, Juhi Bora, John Joseph Kelly, John Andrew Ronald, Arghya Paul   +6 more
wiley   +1 more source