Results 1 to 10 of about 5,340,670 (292)
The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte [PDF]
Frontiers in Cell and Developmental BiologyIntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Toru Suzuki, Toru Suzuki
doaj +2 more sources
Curvature-Induced Membrane Remodeling by the Cell-Penetrating Peptide Pep-1 [PDF]
MembranesThe cell-penetrating peptide Pep-1 interacts with lipid membranes through combined electrostatic and hydrophobic forces, yet the structural details of its membrane remodeling activity remain unclear.
Yasith Indigahawela Gamage, Jianjun Pan
doaj +2 more sources
Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in Pichia pastoris [PDF]
AntibioticsBackground: L2 is formed by combining the pheromone of Streptococcus agalactiae (S. agalactiae) and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing S.
Xuan Li +8 more
doaj +2 more sources
Molecules, 2018 CIGB-552 is a twenty-amino-acid novel synthetic peptide that has proven to be effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Such capability is conferred by its cell-penetrating peptide character, which allows it to enter
Soledad Astrada +3 more
doaj +3 more sources
Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens
Antibiotics, 2022 Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz +3 more
doaj +1 more source
Bioactive Materials, 2022 Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
doaj +1 more source
Cell-Penetrating Peptides and Transportan [PDF]
Pharmaceutics, 2021 In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements.
openaire +3 more sources
A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. [PDF]
PLoS ONE, 2013 Cell-penetrating peptides (CPPs) have proven very effective as intracellular delivery vehicles for various therapeutics. However, there are some concerns about non-specific penetration and cytotoxicity of CPPs for effective cancer treatments.
Ki Jung Lim +6 more
doaj +1 more source
Pharmaceutics, 2023 Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain
Yu-Chen Lo, Wen-Jen Lin
doaj +1 more source
Scientific Reports, 2022 Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
Diego Muñoz-Gacitúa +2 more
doaj +1 more source