Results 1 to 10 of about 142,756 (305)

Cell-Penetrating Peptide–Bismuth Bicycles

Angewandte Chemie, 2023
AbstractCell‐penetrating peptides (CPPs) play a significant role in the delivery of cargos into human cells. We report the first CPPs based on peptide‐bismuth bicycles, which can be readily obtained from commercially available peptide precursors, making them accessible for a wide range of applications.
Saan Voss, Liam D. Adair, Katharina Achazi, Heeyoung Kim, Silke Bergemann, Ralf Bartenschlager, Elizabeth J. New, Jörg Rademann, Christoph Nitsche   +8 more
openaire   +3 more sources

The C-terminal domain of Emi2 conjugated to cell-penetrating peptide activates mouse oocyte [PDF]

Frontiers in Cell and Developmental Biology
IntroductionThe cell cycle of ovulated oocytes from various animal species, including mice, arrests at the second meiotic metaphase until fertilization. The meiotic cell cycle must be initiated to initiate embryonic development.
Toru Suzuki, Toru Suzuki
doaj   +2 more sources

Curvature-Induced Membrane Remodeling by the Cell-Penetrating Peptide Pep-1 [PDF]

Membranes
The cell-penetrating peptide Pep-1 interacts with lipid membranes through combined electrostatic and hydrophobic forces, yet the structural details of its membrane remodeling activity remain unclear.
Yasith Indigahawela Gamage, Jianjun Pan
doaj   +2 more sources

Fusion Partner Facilitates Expression of Cell-Penetrating Peptide L2 in Pichia pastoris [PDF]

Antibiotics
Background: L2 is formed by combining the pheromone of Streptococcus agalactiae (S. agalactiae) and a cell-penetrating peptide (CPP) with cell-penetrating selectivity. L2 has more significant penetration and better specificity for killing S.
Xuan Li, Na Yang, Yuxin Fang, Ruoyu Mao, Ya Hao, Da Teng, Na Dong, Anshan Shan, Jianhua Wang   +8 more
doaj   +2 more sources

Disruptin, a cell-penetrating peptide degrader of EGFR

Translational Oncology, 2021
Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic ...
Ranjit K. Mehta, Sushmita Shukla, Susmita G. Ramanand, Vishal Somnay, Alexander J. Bridges, Theodore S. Lawrence, Mukesh K. Nyati   +6 more
doaj   +3 more sources

Cell-Penetrating Peptides and Transportan [PDF]

Pharmaceutics, 2021
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements.
openaire   +3 more sources

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. [PDF]

Cell
Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA.   +18 more
europepmc   +2 more sources

Cell-Penetrating Antimicrobial Peptides with Anti-Infective Activity against Intracellular Pathogens

Antibiotics, 2022
Cell-penetrating peptides (CPPs) are natural or engineered peptide sequences with the intrinsic ability to internalize into a diversity of cell types and simultaneously transport hydrophilic molecules and nanomaterials, of which the cellular uptake is ...
Gabriela Silva Cruz, Ariane Teixeira dos Santos, Erika Helena Salles de Brito, Gandhi Rádis-Baptista   +3 more
doaj   +1 more source

Selective Moonlighting Cell-Penetrating Peptides [PDF]

Pharmaceutics, 2021
Cell penetrating peptides (CPPs) are molecules capable of passing through biological membranes. This capacity has been used to deliver impermeable molecules into cells, such as drugs and DNA probes, among others. However, the internalization of these peptides lacks specificity: CPPs internalize indistinctly on different cell types. Two major approaches
Rafael Morán-Torres, David A. Castillo González, Maria Luisa Durán-Pastén, Beatriz Aguilar-Maldonado, Susana Castro-Obregón, Gabriel Del Rio   +5 more
openaire   +3 more sources

A manganese (II)-based coordinative dendrimer with robust efficiency in intracellular peptide delivery

Bioactive Materials, 2022
Peptides have gained increasing interests as drug candidates in modern pharmaceutical industry, however, the development of peptide drugs acting on intracellular targets is limited due to their membrane impermeability.
Lanfang Ren, Yang Gao, Yiyun Cheng
doaj   +1 more source