Results 41 to 50 of about 142,957 (305)

hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival

Molecular Therapy: Oncolytics, 2021
hnRNPK is a multifunctional protein that plays an important role in cancer cell proliferation and metastasis via its RNA- and DNA-binding properties.
Pavan Kumar Puvvula, Stephanie Buczkowski, Anne M. Moon   +2 more
doaj   +1 more source

Constrained cell penetrating peptides

Drug Discovery Today: Technologies, 2017
In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them.
S A, Bode, D W P M, Löwik
openaire   +2 more sources

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells

Journal of Pharmacological Sciences, 2008
As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose, Mayumi Takatori, Yoshihiro Kuroda, Mineo Abe, Eri Murata, Tetsuro Isada, Koyo Ueda, Kenji Shigemi, Masayuki Shibazaki, Fumihiro Shimizu, Masashi Hirata, Keita Fukazawa, Masahiro Sakaguchi, Kyoko Kageyama, Yoshifumi Tanaka   +14 more
doaj   +1 more source

Cell-penetrating Peptides [PDF]

Journal of Biological Chemistry, 2003
The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Jean Philippe Richard, Kamran Melikov, Eric Vives, Corinne Ramos, Birgit Verbeure, Mike J. Gait, Leonid V. Chernomordik, Bernard Lebleu   +7 more
openaire   +1 more source

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells [PDF]

, 2014
Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than ...
Blattes, Emilyne, Kammer, Stephan M., Reymond, Jean-Louis, Eggimann, Gabriela A., Darbre, Tamis, Buschor, Stefanie, Biswas, Rasomoy   +6 more
core   +1 more source

A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice

Journal of Pharmacological Sciences, 2010
Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma, Eri Murata, Koyo Ueda, Yoshihiro Kuroda, Ming-Hui Cao, Mineo Abe, Kenji Shigemi, Munetaka Hirose   +7 more
doaj   +1 more source

Novel cell-penetrating peptide-based vectors for siRNA delivery [PDF]

, 2014
Harnessing the RNAi pathway with synthetic siRNA as a potent and selective mode of post-transcriptional gene silencing and has therapeutic potential in personalised medicine; however, the large size and negative charge of siRNA creates a hurdle for ...
Tsimon, M.
core   +1 more source

Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

Pharmaceuticals, 2012
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells
Ülo Langel, Artita Srimanee, Jakob Regberg   +2 more
doaj   +1 more source

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis

JCI Insight, 2021
To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh, Yi-Jia Li, Qianqian Zhao, Chunyan Zhang, Nigus Ambaye, Jieun Song, Toshikage Nagao, Christoph Lahtz, Marwan Fakih, David K. Ann, Hua Yu, Andreas Herrmann   +11 more
doaj   +1 more source