Results 61 to 70 of about 5,340,670 (292)

Using molecular dynamics simulations to prioritize and understand AI-generated cell penetrating peptides

Scientific Reports, 2021
Cell-penetrating peptides have important therapeutic applications in drug delivery, but the variety of known cell-penetrating peptides is still limited.
Duy Phuoc Tran, Seiichi Tada, Akiko Yumoto, Akio Kitao, Yoshihiro Ito, Takanori Uzawa, Koji Tsuda   +6 more
doaj   +1 more source

Cell-Penetrating, Peptide-Based RAFT Agent for Constructing Penetration Enhancers

, 2020
Peptide–polymer conjugates represent a promising class of compounds that can be used to overcome some of the limitations associated with peptides intended for therapeutic and diagnostic applications.
Anja Traeger, Anja Traeger (1797817), San H. Thang (1709089), Anchao Feng, Carlos Guerrero-Sanchez, Friederike Richter, Ulrich S. Schubert, Anchao Feng (2615734), Chao Chen, San H. Thang, Friederike Richter (4882498), Ulrich S. Schubert (411267), Chao Chen (195669), Carlos Guerrero-Sanchez (2014750)   +13 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Effect of small molecule signaling in PepFect14 transfection.

PLoS ONE, 2020
Cell-penetrating peptides can be used to deliver oligonucleotide-based cargoes into cells. Previous studies have shown that the use of small molecule drugs could be an efficient method to increase the efficacy of delivery of oligonucleotides by cell ...
Maxime Gestin, Henrik Helmfors, Luca Falato, Nicola Lorenzon, Filip Ilias Michalakis, Ülo Langel   +5 more
doaj   +1 more source

Cell-penetrating Peptides [PDF]

Journal of Biological Chemistry, 2003
The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Jean Philippe Richard, Kamran Melikov, Eric Vives, Corinne Ramos, Birgit Verbeure, Mike J. Gait, Leonid V. Chernomordik, Bernard Lebleu   +7 more
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Known non-penetrating cell-penetrating peptide analogs and peptide hormones.

, 2013
Known non-penetrating cell-penetrating peptide analogs and peptide hormones.
C. Ian Johnston (348110), Kenneth O. Willeford (348111), Shane C. Burgess (22951), William S. Sanders (348109), Susan M. Bridges (22947)   +4 more
core   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]

British Journal of Pharmacology, 2005
Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W., Christison, Richard, Bundell, Ken, Voyce, Catherine J., Brockbank, Sarah M V, Newham, Peter, Lindsay, Mark A.   +6 more
openaire   +2 more sources

Curcumin displays enhanced solubility and antibacterial activities when complexed with the cell penetrating peptide pVEC

, 2022
Curcumin is among phytochemicals with increasing popularity; unfortunately, its therapeutic potential is restricted due to poor water solubility and bioavailability.
SARIYAR AKBULUT, BERNA
core   +1 more source