Results 51 to 60 of about 5,794,985 (290)
Cell-penetrating peptide exploited syndecans
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010 Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas +8 more
openaire +3 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2022 Curcumin is among phytochemicals with increasing popularity; unfortunately, its therapeutic potential is restricted due to poor water solubility and bioavailability.
Acar, Tayfun +7 more
core +2 more sources
Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K
Scientific Reports, 2023 Given the widespread demand for novel antibacterial agents, we modified a cell-penetrating peptide (KFF)3K to transform it into an antibacterial peptide.
Julia Macyszyn +6 more
doaj +1 more source
Cyclical, Cell-Penetrating, Peptide-Protein Fusions [PDF]
, 2017 The expression of recombinant proteins often exploits amino acid motifs that can provide unique properties for recognition, post-translational modification, binding capacity, and translocation potential.
Kerwin, John Forbes
core +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Novel cell-penetrating peptide-based vectors for siRNA delivery [PDF]
, 2014 Harnessing the RNAi pathway with synthetic siRNA as a potent and selective mode of post-transcriptional gene silencing and has therapeutic potential in personalised medicine; however, the large size and negative charge of siRNA creates a hurdle for ...
Tsimon, M.
core +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
International Journal of Pharmaceutics: X, 2022 Targeting, detecting, and destroying selectively cancer cells or specific organelles is a major challenge of nanomedicine. Recently, a new methodology was conceived to synthesize gold nanoparticles combined with a peptide having a C-terminal biotin (BIOT-
A. Griveau +3 more
doaj +1 more source
Improving antitumor targeting via using PL3 homing peptide and cell-penetrating peptide [PDF]
, 2023 This study aims to improve antitumor targeting in prostate cancer via uploading a drug to a DDS comprised of a cell penetrating peptide decorated with a tumor-homing peptide ...
Shafq Al-azzawi, Dhafir Masheta
core