Results 51 to 60 of about 142,957 (305)

A brief introduction to cell‐penetrating peptides [PDF]

Journal of Molecular Recognition, 2003
AbstractCell membranes act as protective walls to exclude most molecules that are not actively imported by living cells. This is an efficient way for a cell to prevent uncontrolled influx or efflux of solutes, which otherwise would be harmful to it.
Pontus, Lundberg, Ulo, Langel
openaire   +2 more sources

Cell-penetrating peptide exploited syndecans

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010
Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas, Keller-Pinter, Aniko, Kusz, Erzsebet, Kolozsi, Csongor, Bozso, Zsolt, Toth, Gabor, Vizler, Csaba, Olah, Zoltan, Szilak, Laszlo   +8 more
openaire   +3 more sources

Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin

Materials & Design, 2023
Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li, Yajiang Yuan, Zhongming Zhang, Xiuming Zhang, Hui Yang, Huanan Li, Bao Han, Ziyang Deng, Zipeng Zhou, Xiangyi Fan   +9 more
doaj   +1 more source

Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin [PDF]

, 2003
Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY.
Dominga Deluca, Schaschke, N., Gil-Parrado, S, Werner M.a.c.h.l.e.i.d.t., Luis Moroder, Dietmar Pfeiler, Irmgard Assfalg Machleidt, Machleidt, Werner, Fiorino, F, Pfeiler, D., Pfeiler, D, Machleidt, W, Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Moroder, L, Deluca, D, Gil-Parrado, S., Moroder, L., Machleidt, W., Fiorino, F., Assfalg-Machleidt, I, Norbert Schaschke, Deluca, D., Assfalg-Machleidt, I., FIORINO, FERDINANDO, Shirley Gil Parrado   +25 more
core   +1 more source

Non-metabolic membrane tubulation and permeability induced by bioactive peptides. [PDF]

PLoS ONE, 2007
BACKGROUND:Basic cell-penetrating peptides are potential vectors for therapeutic molecules and display antimicrobial activity. The peptide-membrane contact is the first step of the sequential processes leading to peptide internalization and cell activity.
Antonin Lamazière, Fabienne Burlina, Claude Wolf, Gérard Chassaing, Germain Trugnan, Jesus Ayala-Sanmartin   +5 more
doaj   +1 more source

Properties of cell penetrating peptides (CPPs) [PDF]

IUBMB Life, 2006
Different approaches have been developed for the introduction of macromolecules, proteins and DNA into target cells. Viral (retroviruses, lentiviruses, etc.) and nonviral (liposomes, bioballistics etc.) vectors as well as lipid particles have been tested as DNA delivery systems.
Alexandre, Kerkis, Mirian A F, Hayashi, Tetsuo, Yamane, Irina, Kerkis   +3 more
openaire   +2 more sources

Peptide-based delivery of therapeutics in cancer treatment

Materials Today Bio, 2022
Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity.
Timothy Samec, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant   +4 more
doaj   +1 more source

Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin [PDF]

, 2002
Schaschke N, Deluca D, Assfalg-Machleidt I, Hohneke C, Sommerhoff CP, Machleidt W. Epoxysuccinyl peptide-derived cathepsin B inhibitors: Modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin.
Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Schaschke, N., Deluca, D, Sommerhoff, C. P., Höhneke, C., Sommerhoff, CP, Machleidt, W., Assfalg-Machleidt, I, Machleidt, Werner, Deluca, D., Deluca, Dominga, Sommerhoff, Christian P., Assfalg-Machleidt, I., Hohneke, C, Höhneke, Clara, Machleidt, W   +16 more
core   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Assessment of cellular uptake and endosomal release of a cell-penetrating peptide in Mus musculus liver tissue

, 2023
The selective permeability of the lipid bilayer poses an enormous challenge to intracellularly active drugs. Here we investigate the ability of a cell-penetrating peptide (CPP) to traverse the plasma membrane in Mus musculus liver tissue.
Nguyen, Hai Dang
core