Results 31 to 40 of about 142,756 (305)
Constrained cell penetrating peptides
Drug Discovery Today: Technologies, 2017 In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them.
S A, Bode, D W P M, Löwik
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Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Pharmaceuticals, 2010 The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo +3 more
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Cell-penetrating Peptides [PDF]
Journal of Biological Chemistry, 2003 The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Jean Philippe Richard +7 more
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Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells [PDF]
, 2014 Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than ...
Blattes, Emilyne +6 more
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A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
Journal of Pharmacological Sciences, 2010 Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma +7 more
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Novel cell-penetrating peptide-based vectors for siRNA delivery [PDF]
, 2014 Harnessing the RNAi pathway with synthetic siRNA as a potent and selective mode of post-transcriptional gene silencing and has therapeutic potential in personalised medicine; however, the large size and negative charge of siRNA creates a hurdle for ...
Tsimon, M.
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Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
JCI Insight, 2021 To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh +11 more
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Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Pharmaceuticals, 2012 Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells
Ülo Langel +2 more
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A brief introduction to cell‐penetrating peptides [PDF]
Journal of Molecular Recognition, 2003 AbstractCell membranes act as protective walls to exclude most molecules that are not actively imported by living cells. This is an efficient way for a cell to prevent uncontrolled influx or efflux of solutes, which otherwise would be harmful to it.
Pontus, Lundberg, Ulo, Langel
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Materials & Design, 2023 Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li +9 more
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