Results 31 to 40 of about 73,644 (303)
Cell-penetrating peptide exploited syndecans
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2010 Cell-penetrating peptides (CPPs) are short peptides capable of translocating across the plasma membrane of live cells and transporting conjugated compounds intracellularly. Fifteen years after discovering the first model cationic CPPs, penetratin and TAT, CPP internalization is still challenging many questions.
Letoha, Tarnas +8 more
openaire +3 more sources
Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]
, 2016 Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James +11 more
core +2 more sources
A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
Journal of Pharmacological Sciences, 2010 Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma +7 more
doaj +1 more source
Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis
JCI Insight, 2021 To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh +11 more
doaj +1 more source
Cell-penetrating peptides [PDF]
Plant Signaling & Behavior, 2008 Internalization of cell-penetrating peptides, well described in mammalian cell system, has recently been reported in a range of plant cells by three independent groups. Despite fundamental differences between animal cell and plant cell composition, the CPP uptake pattern between the mammalian system and the plant system is very similar. Tat, Tat-2 pVEC
François, Eudes, Archana, Chugh
openaire +2 more sources
Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies
Pharmaceuticals, 2012 Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells
Ülo Langel +2 more
doaj +1 more source
New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]
, 2017 Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián +7 more
core +1 more source
Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]
British Journal of Pharmacology, 2005 Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W. +6 more
openaire +2 more sources
Materials & Design, 2023 Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li +9 more
doaj +1 more source
Use of single-chain antibody derivatives for targeted drug delivery [PDF]
, 2016 Single-chain antibodies (scFvs), which contain only the variable domains of full-length antibodies, are relatively small molecules that can be used for selective drug delivery.
Ahmadzadeh, V. +5 more
core +1 more source