Results 31 to 40 of about 5,340,670 (292)

Potent antitumor effects of cell-penetrating peptides targeting STAT3 axis

JCI Insight, 2021
To date, there are no inhibitors that directly and specifically target activated STAT3 and c-Myc in the clinic. Although peptide-based inhibitors can selectively block activated targets, their clinical usage is limited because of low cell penetration and/
Maryam Aftabizadeh, Yi-Jia Li, Qianqian Zhao, Chunyan Zhang, Nigus Ambaye, Jieun Song, Toshikage Nagao, Christoph Lahtz, Marwan Fakih, David K. Ann, Hua Yu, Andreas Herrmann   +11 more
doaj   +1 more source

Uptake of cell‐penetrating peptides in yeasts [PDF]

FEBS Letters, 2005
The uptake of different cell‐penetrating peptides (CPPs) in two yeast species, Saccharomyces cerevisiae and Candida albicans, was studied using fluorescence HPLC‐analyses of cell content. Comparison of the ability of penetratin, pVEC and (KFF)3K to traverse the yeast cell envelope shows that the cellular uptake of the peptides varies widely.
Holm, Tina, Netzereab, Semharai, Hansen, Mats, Langel, Ülo, Hällbrink, Mattias   +4 more
openaire   +2 more sources

Novel cell-penetrating peptide-based vectors for siRNA delivery [PDF]

, 2014
Harnessing the RNAi pathway with synthetic siRNA as a potent and selective mode of post-transcriptional gene silencing and has therapeutic potential in personalised medicine; however, the large size and negative charge of siRNA creates a hurdle for ...
Tsimon, M.
core   +1 more source

Applications of Cell-Penetrating Peptides for Tumor Targeting and Future Cancer Therapies

Pharmaceuticals, 2012
Cell-penetrating peptides provide a highly promising strategy for intracellular drug delivery. One relevant clinical application of cell-penetrating peptides is cancer therapeutics. Peptide based delivery could increase the uptake of drugs in tumor cells
Ülo Langel, Artita Srimanee, Jakob Regberg   +2 more
doaj   +1 more source

Cell penetrating peptide modified M2 macrophage derived exosomes treat spinal cord injury and rheumatoid arthritis by loading curcumin

Materials & Design, 2023
Effectively suppressing the hyperactivated inflammatory response is a critical strategy for treating inflammatory diseases, such as spinal cord injury (SCI) and rheumatoid arthritis (RA).
Zhuo Li, Yajiang Yuan, Zhongming Zhang, Xiuming Zhang, Hui Yang, Huanan Li, Bao Han, Ziyang Deng, Zipeng Zhou, Xiangyi Fan   +9 more
doaj   +1 more source

Constrained cell penetrating peptides

Drug Discovery Today: Technologies, 2017
In this review we provide an overview of recent developments in the field of cell penetrating peptides (CPPs) on research that aims to achieve better control over their transduction properties - one of the big challenges - by means of restraining them.
S A, Bode, D W P M, Löwik
openaire   +2 more sources

Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin [PDF]

, 2003
Gil-Parrado S, Assfalg-Machleidt I, Fiorino F, et al. Calpastatin exon 1B-derived peptide, a selective inhibitor of calpain: Enhancing cell permeability by conjugation with penetratin. BIOLOGICAL CHEMISTRY.
Dominga Deluca, Schaschke, N., Gil-Parrado, S, Werner M.a.c.h.l.e.i.d.t., Luis Moroder, Dietmar Pfeiler, Irmgard Assfalg Machleidt, Machleidt, Werner, Fiorino, F, Pfeiler, D., Pfeiler, D, Machleidt, W, Schaschke, Norbert, Assfalg-Machleidt, Irmgard, Moroder, L, Deluca, D, Gil-Parrado, S., Moroder, L., Machleidt, W., Fiorino, F., Assfalg-Machleidt, I, Norbert Schaschke, Deluca, D., Assfalg-Machleidt, I., FIORINO, FERDINANDO, Shirley Gil Parrado   +25 more
core   +1 more source

Non-metabolic membrane tubulation and permeability induced by bioactive peptides. [PDF]

PLoS ONE, 2007
BACKGROUND:Basic cell-penetrating peptides are potential vectors for therapeutic molecules and display antimicrobial activity. The peptide-membrane contact is the first step of the sequential processes leading to peptide internalization and cell activity.
Antonin Lamazière, Fabienne Burlina, Claude Wolf, Gérard Chassaing, Germain Trugnan, Jesus Ayala-Sanmartin   +5 more
doaj   +1 more source

Novel Cell-Penetrating Peptide Conjugated Proteasome Inhibitors: Anticancer and Antifungal Investigations. [PDF]

, 2019
Cell-penetrating peptide conjugated peptide aldehydes Tat-A and Tat-B showed low micromolar anticancer and antifungal activities and synergistic action in combination with cisplatin and amphotericin B against cancer and fungal cells, respectively.
Reynisson
core   +1 more source

Peptide-based delivery of therapeutics in cancer treatment

Materials Today Bio, 2022
Current delivery strategies for cancer therapeutics commonly cause significant systemic side effects due to required high doses of therapeutic, inefficient cellular uptake of drug, and poor cell selectivity.
Timothy Samec, Jessica Boulos, Serena Gilmore, Anthony Hazelton, Angela Alexander-Bryant   +4 more
doaj   +1 more source