Matrix stiffness affects endocytic uptake of MK2-inhibitor peptides.
PLoS ONE, 2014 In this study, the role of substrate stiffness on the endocytic uptake of a cell-penetrating peptide was investigated. The cell-penetrating peptide, an inhibitor of mitogen-activated protein kinase activated protein kinase II (MK2), enters a primary ...
Jamie L Brugnano, Alyssa Panitch
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Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac. [PDF]
PLoS ONE, 2016 This study demonstrates the effectiveness of a peptide shuttle in delivering diclofenac into and through human epidermis. Diclofenac was conjugated to a novel phenylalanyl-N-methyl-naphthalenylalanine-derived diketopiperazine (DKP) shuttle and to TAT (a ...
Yousuf Mohammed +4 more
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Cell Penetration Properties of a Highly Efficient Mini Maurocalcine Peptide
Pharmaceuticals, 2013 Maurocalcine is a highly potent cell-penetrating peptide isolated from the Tunisian scorpion Maurus palmatus. Many cell-penetrating peptide analogues have been derived from the full-length maurocalcine by internal cysteine substitutions and sequence ...
Michel De Waard +5 more
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hnRNPK-derived cell-penetrating peptide inhibits cancer cell survival
Molecular Therapy: Oncolytics, 2021 hnRNPK is a multifunctional protein that plays an important role in cancer cell proliferation and metastasis via its RNA- and DNA-binding properties.
Pavan Kumar Puvvula +2 more
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Glycosylated Cell‐Penetrating Peptides (GCPPs) [PDF]
ChemBioChem, 2019 AbstractThe cell membrane regulates the exchange of molecules and information with the external environment. However, this control barrier hinders the delivery of exogenous bioactive molecules that can be applied to correct cellular malfunctions. Therefore, the traffic of macromolecules across the cell membrane represents a great challenge for the ...
Iván Gallego +8 more
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Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Journal of Pharmacological Sciences, 2008 As TrkA, a high-affinity receptor of nerve growth factor (NGF), is a potential target for relieving uncontrolled inflammatory pain, an effective inhibitor of TrkA has been required for pain management.
Munetaka Hirose +14 more
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Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
Pharmaceuticals, 2010 The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo +3 more
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Arginine‐rich cell‐penetrating peptides [PDF]
FEBS Letters, 2009 Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a
Schmidt, Nathan +3 more
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Effects of the vasoactive intestinal peptide (VIP) and related peptides on glioblastoma cell growth in vitro [PDF]
, 2003 The growth rate of numerous cancer cell lines is regulated in part by actions of neuropeptides of the vasoactive intestinal peptide (VIP) family, which also includes pituitary adenylate cyclase-activating peptide (PACAP), glucagon, and peptide histidine ...
Dufès, Christine +4 more
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A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
Journal of Pharmacological Sciences, 2010 Nerve growth factor (NGF) and its high-affinity receptor, TrkA, are one of the targets in the production of new drugs for the treatment of neuropathic pain.
Wei-Ying Ma +7 more
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