Results 11 to 20 of about 73,644 (303)

Arginine‐rich cell‐penetrating peptides [PDF]

FEBS Letters, 2009
Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a
Schmidt, Nathan, Mishra, Abhijit, Lai, Ghee Hwee, Wong, Gerard C.L.   +3 more
openaire   +2 more sources

A cancer specific cell-penetrating peptide, BR2, for the efficient delivery of an scFv into cancer cells. [PDF]

PLoS ONE, 2013
Cell-penetrating peptides (CPPs) have proven very effective as intracellular delivery vehicles for various therapeutics. However, there are some concerns about non-specific penetration and cytotoxicity of CPPs for effective cancer treatments.
Ki Jung Lim, Bong Hyun Sung, Ju Ri Shin, Young Woong Lee, Da Jung Kim, Kyung Seok Yang, Sun Chang Kim   +6 more
doaj   +1 more source

RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry. [PDF]

Cell
Perr J, Langen A, Almahayni K, Nestola G, Chai P, Lebedenko CG, Volk RF, Detrés D, Caldwell RM, Spiekermann M, Hemberger H, Bisaria N, Aiba T, Sánchez-Rivera FJ, Tzelepis K, Calo E, Möckl L, Zaro BW, Flynn RA.   +18 more
europepmc   +2 more sources

Cell-Penetrating Peptides and Transportan [PDF]

Pharmaceutics, 2021
In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements.
openaire   +3 more sources

Insights into the equilibrium structure and translocation mechanism of TP1, a spontaneous membrane-translocating peptide

Scientific Reports, 2022
Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
Diego Muñoz-Gacitúa, Fanny Guzman, Boris Weiss-López   +2 more
doaj   +1 more source

Improve BBB Penetration and Cytotoxicity of Palbociclib in U87-MG Glioblastoma Cells Delivered by Dual Peptide Functionalized Nanoparticles

Pharmaceutics, 2023
Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain
Yu-Chen Lo, Wen-Jen Lin
doaj   +1 more source

A novel CAV derived cell-penetrating peptide efficiently delivers exogenous molecules through caveolae-mediated endocytosis

Veterinary Research, 2018
Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix.
Gaowei Hu, Wenlv Zheng, Ao Li, Yaru Mu, Mingyu Shi, Tuofan Li, Haitao Zou, Hongxia Shao, Aijian Qin, Jianqiang Ye   +9 more
doaj   +1 more source

Cell-penetrating peptides and their analogues as novel nanocarriers for drug delivery [PDF]

BioImpacts, 2015
Introduction: The impermeability of biological membranes is a major obstacle in drug delivery; however, some peptides have transition capabilities of biomembranes.
Samira Jafari, Solmaz Maleki Dizaj, khosro adibkia   +2 more
doaj   +1 more source

Designed Multifunctional Peptides for Intracellular Targets

Antibiotics, 2022
Nature’s way for bioactive peptides is to provide them with several related functions and the ability to cooperate in performing their job. Natural cell-penetrating peptides (CPP), such as penetratins, inspired the design of multifunctional constructs ...
Davor Juretić
doaj   +1 more source

Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides [PDF]

, 2018
A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.
Gannon, Susan, Hezwani, Mohammed, Liskamp, Rob M.J., Pirvan, Alin, Postma, Tobias, Riehle, Mathis, Silva Nigenda, Ezequiel, Smith, Carol-Anne   +7 more
core   +1 more source