Results 11 to 20 of about 5,794,985 (290)
Cell-Penetrating Peptide–Bismuth Bicycles [PDF]
Angewandte Chemie, 2023 Cell-penetrating peptides (CPPs) play a significant role in the delivery of cargos into human cells for a wide range of therapeutic and diagnostic applications. We disclose the first CPPs based on peptide–bismuth bicycles, which can be readily obtained from commercially available peptide precursors, making them highly accessible for a wide range of ...
Saan Voss +8 more
openaire +4 more sources
Veterinary Research, 2018 Cell-penetrating peptide (CPP) is a promising cargo for delivering bioactive molecules. In this study, the N terminus of VP1 from chicken anemia virus, designated as CVP1, was found to carry enriched arginine residues with α-helix.
Gaowei Hu +9 more
doaj +2 more sources
Classes of Cell-Penetrating Peptides
, 2015 During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
openaire +3 more sources
Characterisation of cell‐penetrating peptide‐mediated peptide delivery [PDF]
British Journal of Pharmacology, 2005 Cell‐penetrating peptides such as antennapedia, TAT, transportan and polyarginine have been extensively employed for in vitro and in vivo delivery of biologically active peptides. However, little is known of the relative efficacy, toxicity and uptake mechanism of individual protein transduction domain–peptide conjugates, factors that will be critical
Jones, Simon W. +6 more
openaire +3 more sources
Disruptin, a cell-penetrating peptide degrader of EGFR
Translational Oncology, 2021 Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic ...
Ranjit K. Mehta +6 more
doaj +3 more sources
Prediction of Cell-Penetrating Peptides
, 2015 The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
openaire +3 more sources
International Journal of Nanomedicine, 2012 Nian-Qiu Shi, Wei Gao, Bai Xiang, Xian-Rong QiDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Peking University, Beijing, People's Republic of ChinaAbstract: The use of activable cell-penetrating peptides (ACPPs) as molecular ...
Shi NQ, Gao W, Xiang B, Qi XR
doaj +1 more source
Cell-Penetrating Peptides and Transportan [PDF]
Pharmaceutics, 2021 In the most recent 25–30 years, multiple novel mechanisms and applications of cell-penetrating peptides (CPP) have been demonstrated, leading to novel drug delivery systems. In this review, I present a brief introduction to the CPP area with selected recent achievements.
openaire +3 more sources
Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells [PDF]
, 2014 Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than ...
Blattes, Emilyne +13 more
core +3 more sources
Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity [PDF]
, 2011 Attaching peptides to metallodrugs may result in improved biological properties of the complexes. The potential use of cell penetrating peptides (CPPs) as cell delivery vectors is attractive, since directed cell uptake of (metallo)drugs remains a major ...
Rijt, Sabine H. van +7 more
core +1 more source