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Cell-Penetrating Peptides as Passive Permeation Enhancers for Transdermal Drug Delivery
AAPS PharmSciTech, 2022Cell-penetrating peptides have been widely used as a tool to gain access to cytosol for numerous applications. The review highlights the advances made in preclinical and clinical research using cell-penetrating peptides since their discovery in 1980s ...
L. Chablani, Vijay A. Singh
semanticscholar +1 more source
Trends in Pharmacological Sciences, 2000
The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren +3 more
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The established view in cellular biology dictates that the cellular internalization of hydrophilic macromolecules can only be achieved through the classical endocytosis pathway. However, in the past five years several peptides have been demonstrated to translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway.
M, Lindgren +3 more
openaire +2 more sources
Predicting cell-penetrating peptides
Advanced Drug Delivery Reviews, 2008Possibility to predict short peptide sequences capable to penetrate the plasma membrane opens new opportunities for developing peptide based intracellular delivery vectors, called cell-penetrating peptides (CPPs). Predictions of CPPs, however are often based on trial and error and may not always lead to new potent sequences.
Mats, Hansen, Kalle, Kilk, Ulo, Langel
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Progress in tumour-targeted drug delivery based on cell-penetrating peptides
Journal of drug targeting (Print), 2021Since the discovery of cell-penetrating peptides (CPP) in the 1980s, they have played a unique role in various fields owing to their excellent and unique cell membrane penetration function.
Xinru Kong +5 more
semanticscholar +1 more source
Biomaterials Science, 2020
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell continues to be an ultimate challenge. There are many physicochemical factors such as charge, size and molecular weight of the molecules and delivery vehicles,
Kalyani Desale +2 more
semanticscholar +1 more source
In the field of nanotherapeutics, gaining cellular entry into the cytoplasm of the target cell continues to be an ultimate challenge. There are many physicochemical factors such as charge, size and molecular weight of the molecules and delivery vehicles,
Kalyani Desale +2 more
semanticscholar +1 more source
Intracellulartransduction using cell-penetrating peptides
Mol. BioSyst., 2010Cell penetrating peptides (CPPs), TATp, in particular, has been used widely for intracellular delivery of various agents ranging from small molecules to proteins, peptides, range of pharmaceutical nanocarriers and imaging agents. This review highlights the mechanisms of CPP-mediated delivery and summarizes numerous examples illustrating the potential ...
Rupa, Sawant, Vladimir, Torchilin
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Cell penetrating peptides: the potent multi-cargo intracellular carriers
Expert Opinion on Drug Delivery, 2019Introduction: Cell penetrating peptides (CPPs) known as protein translocation domains (PTD), membrane translocating sequences (MTS), or Trojan peptides (TP) are able to cross biological membranes without clear toxicity using different mechanisms, and ...
Kimia Kardani +3 more
semanticscholar +1 more source
Prediction of Cell-Penetrating Peptides
2015The in silico methods for the prediction of the cell-penetrating peptides are reviewed. Those include the multivariate statistical methods, machine-learning methods such as the artificial neural networks and support vector machines, and molecular modeling techniques including molecular docking and molecular dynamics.The applicability of the methods is ...
Mattias, Hällbrink, Mati, Karelson
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Proteomimetic Cell Penetrating Peptides
International Journal of Peptide Research and Therapeutics, 2008QSAR analysis of the primary sequence of human cytochrome c indicated that numerous putative cell penetrating peptide sequences are located within major amino- and carboxyl-terminal helical domains. Two such sequences, Cyt c77−101 and the shorter homologue Cyt c86−101, readily translocate the plasma membrane of U373MG astrocytoma cells but ...
John Howl, Sarah Jones
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ACS Applied Materials and Interfaces, 2020
The significance of the complex bacterial ecosystem in the human body and the impediment of the mammalian membrane against many antibiotics together emphasize the necessity to develop antimicrobial agents with precise antimicrobial and cell-penetrating ...
Jiawei Li +8 more
semanticscholar +1 more source
The significance of the complex bacterial ecosystem in the human body and the impediment of the mammalian membrane against many antibiotics together emphasize the necessity to develop antimicrobial agents with precise antimicrobial and cell-penetrating ...
Jiawei Li +8 more
semanticscholar +1 more source