Results 351 to 360 of about 395,472 (375)

Classes of Cell-Penetrating Peptides

2015
During the three decades of cell-penetrating peptides era the superfamily of CPPs has rapidly expanded, and the quest for new sequences continues. CPPs have been well recognized by scientific community and they have been used for transduction of a wide variety of molecules and particles into cultured cells and in vivo.
Margus, Pooga, Ülo, Langel
openaire   +2 more sources

The Pharmacokinetics of Cell-Penetrating Peptides

Molecular Pharmaceutics, 2010
Cell-penetrating peptides (CPPs) are able to penetrate the cell membrane carrying cargoes such as peptides, proteins, oligonucleotides, siRNAs, radioisotopes, liposomes, and nanoparticles. Consequently, many delivery approaches have been developed to use CPPs as tools for drug delivery.
Dikran, Sarko, Barbro, Beijer, Regine, Garcia Boy, Eva-Maria, Nothelfer, Karin, Leotta, Michael, Eisenhut, Annette, Altmann, Uwe, Haberkorn, Walter, Mier   +8 more
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Cell-penetrating Peptide-mediated Nanovaccine Delivery

Current Drug Targets, 2021
Vaccination with small antigens, such as proteins, peptides, or nucleic acids, is used to activate the immune system and trigger the protective immune responses against a pathogen. Currently, nanovaccines are undergoing development instead of conventional vaccines.
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pH-responsive PepFect cell-penetrating peptides

International Journal of Pharmaceutics, 2016
A series of cell-penetrating PepFect peptide analogues was developed by substitutions of the galanin-derived N-terminal sequence. Histidine modifications were incorporated in order to make the peptides pH-responsive. The peptides were all able to form non-covalent complexes with an oligonucleotide cargo by co-incubation in buffer.
Regberg, Jakob; Vasconcelos, Luis; Madani, Fatemeh; Langel, Ulo; Hallbrink, Mattias   +5 more
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Cyclic Cell-Penetrating Peptides As Efficient Intracellular Drug Delivery Tools.

Molecular Pharmaceutics, 2019
Cyclic cell-penetrating peptides are relatively a newer class of peptides that have a huge potential for the intracellular delivery of therapeutic agents aimed at treating challenging ailments like multidrug resistance bacterial diseases, cancer, and HIV
Shang Eun Park, M. Sajid, K. Parang, R. Tiwari   +3 more
semanticscholar   +1 more source

Proline-rich, amphipathic cell-penetrating peptides

Advanced Drug Delivery Reviews, 2008
Proline-rich peptides are a chemically and structurally diverse family of cell-penetrating vectors characterised by the presence of pyrrolidine rings from prolines. Amphipathic Pro-rich peptides are particularly effective, demonstrating efficient cellular uptake and non-cytotoxicity.
Sílvia, Pujals, Ernest, Giralt
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Cell Penetrating Peptides for Tumor Targeting

Current Pharmaceutical Biotechnology, 2011
Anticancer drug delivery has been hindered due to cell membrane permeability and the lack of a selective marker for tumor cells. Cell permeability is related to the bioavailability of drugs and has therefore been considered to be an essential step for achieving therapeutic efficacy.
Young Suk, Choi, Jue Yeon, Lee, Jin Sook, Suh, Seung Jin, Lee, Victor C, Yang, Chong Pyoung, Chung, Yoon Jeong, Park   +6 more
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Therapeutic Potential of cell-penetrating Peptides

Therapeutic Delivery, 2013
The ability of cell-penetrating peptides to cross plasma membranes has been used for various applications, including the delivery of bioactive molecules to inhibit disease-producing cellular mechanisms. Selective drug delivery into target cells improves drug distribution and decreases dosing and toxicity.
Luís, Vasconcelos, Kalle, Pärn, Ulo, Langel   +2 more
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Cell Penetrating Peptides in Drug Delivery

Pharmaceutical Research, 2004
Protein transduction domains (PTDs) are small cationic peptides that can facilitate the uptake of large, biologically active molecules into mammalian cells. Recent reports have suggested that PTDs may be able to mediate the delivery of cargo to tissues throughout a living organism.
Eric L, Snyder, Steven F, Dowdy
openaire   +2 more sources

Targeted Subcellular Protein Delivery Using Cleavable Cyclic Cell-Penetrating Peptides.

Bioconjugate chemistry, 2019
The delivery of entire functional proteins into living cells is a long-sought goal in science. Cyclic cell-penetrating peptides (cCPPs) have proven themselves to be potent delivery vehicles to carry proteins upon conjugation into the cytosol of living ...
Anselm F. L. Schneider, A. Wallabregue, Luise Franz, C. Hackenberger   +3 more
semanticscholar   +1 more source