Results 1 to 10 of about 11,304,397 (389)

Cell Adhesion by Integrins [PDF]

Physiological Reviews, 2019
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions.
Michael Bachmann, Sampo Kukkurainen, Vesa P. Hytönen, Bernhard Wehrle-Haller   +3 more
openaire   +6 more sources

Criticality in Cell Adhesion [PDF]

Physical Review X, 2021
Version accepted for publication in Physical Review ...
Kristian Blom, Aljaž Godec
openaire   +6 more sources

Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments

Communications Biology, 2023
CryoEM structures capture the initial α-catenin interaction with F-actin before the sensing of force.
Erumbi S. Rangarajan, Emmanuel W. Smith, Tina Izard   +2 more
doaj   +1 more source

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Nature Communications, 2021
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour   +8 more
doaj   +1 more source

miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion

Scientific Reports, 2021
The ability of integrins on the cell surface to mediate cell adhesion to the extracellular matrix ligands is regulated by intracellular signaling cascades.
Gideon Obeng, Eun Jeong Park, Michael G. Appiah, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +5 more
doaj   +1 more source

Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) have emerged as key players of intercellular communication and mediate crosstalk between tissues. Metastatic tumors release tumorigenic EVs, capable of pre-conditioning distal sites for organotropic metastasis.
Samuel Darkwah, Eun Jeong Park, Phyoe Kyawe Myint, Atsushi Ito, Atsushi Ito, Michael G. Appiah, Gideon Obeng, Eiji Kawamoto, Eiji Kawamoto, Motomu Shimaoka   +9 more
doaj   +1 more source

Cell Adhesion in Cancer [PDF]

International Journal of Cell Biology, 2012
During cancer progression, cells lose their original tissue contacts, move through the extracellular matrix (ECM), enter into the lymphatic and/or blood system, extravasate, and ultimately form new tumors. Therefore, tumor cells inevitably experience alterations in cell-cell and cell-ECM adhesion and the transformation activities of tumor cells are ...
Eok-Soo Oh, Motoharu Seiki, Martin Gotte, Jun Chung   +3 more
openaire   +4 more sources

The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria

BMC Molecular and Cell Biology, 2020
Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its expression is downregulated in both
Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama, Klaus Ebnet   +11 more
doaj   +1 more source

Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins

Diagnostic Pathology, 2020
Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches.
Phyoe Kyawe Myint, Eun Jeong Park, Arong Gaowa, Eiji Kawamoto, Motomu Shimaoka   +4 more
doaj   +1 more source

The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells

Viruses, 2021
The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +9 more
doaj   +1 more source