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Cell Adhesion by Integrins [PDF]
Physiological Reviews, 2019 Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions.
Michael Bachmann +3 more
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Cold Spring Harbor Perspectives in Biology, 2012 Chemical synapses are asymmetric intercellular junctions that mediate synaptic transmission. Synaptic junctions are organized by trans-synaptic cell adhesion molecules bridging the synaptic cleft. Synaptic cell adhesion molecules not only connect pre- and postsynaptic compartments, but also mediate trans-synaptic recognition and signaling processes ...
Markus, Missler +2 more
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Ligand-competent fractalkine receptor is expressed on exosomes
Biochemistry and Biophysics Reports, 2021 Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park +9 more
doaj +1 more source
Viruses, 2021 The spike glycoprotein attached to the envelope of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to and exploits angiotensin-converting enzyme 2 (ACE2) as an entry receptor to infect pulmonary epithelial cells.
Eun Jeong Park +9 more
doaj +1 more source
Targeted remodeling of breast cancer and immune cell homing niches by exosomal integrins
Diagnostic Pathology, 2020 Exosomes represent an important subset of extracellular vesicles involved in inter-cellular communications in health and diseases. Exosomes secreted from cancer and immune cells travel to the specific tissues containing homing niches.
Phyoe Kyawe Myint +4 more
doaj +1 more source
Modelling adhesion-independent cell migration [PDF]
, 2020 A two-dimensional mathematical model for cells migrating without adhesion capabilities is presented and analyzed. Cells are represented by their cortex, which is modelled as an elastic curve, subject to an internal pressure force.
Jankowiak, Gaspard +4 more
core +5 more sources
Conformational flexibility determines the Nf2/merlin tumor suppressor functions
Matrix Biology Plus, 2021 The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth.
Marina C. Primi +3 more
doaj +1 more source
Tenomodulin expression in the periodontal ligament enhances cellular adhesion. [PDF]
, 2013 Tenomodulin (Tnmd) is a type II transmembrane protein characteristically expressed in dense connective tissues such as tendons and ligaments. Its expression in the periodontal ligament (PDL) has also been demonstrated, though the timing and function ...
Chung, Ung-Il +10 more
core +6 more sources
Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes [PDF]
, 2016 Desmosomes are adhesion plaques that mediate cell-cell adhesion in many tissues, including the epidermis, and generate mechanical resistance to tissues. The extracellular domains of desmosomal cadherin proteins, desmogleins and desmocollins, are required
Ali, Jawahir +7 more
core +1 more source
Cell Adhesion at the Tight Junctions: New Aspects and New Functions
Cells, 2023 Tight junctions (TJ) are cell–cell adhesive structures that define the permeability of barrier-forming epithelia and endothelia. In contrast to this seemingly static function, TJs display a surprisingly high molecular complexity and unexpected dynamic ...
Nicolina Wibbe, Klaus Ebnet
doaj +1 more source