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Cell Adhesion by Integrins [PDF]

Physiological Reviews, 2019
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions.
Michael Bachmann, Sampo Kukkurainen, Vesa P. Hytönen, Bernhard Wehrle-Haller   +3 more
openaire   +4 more sources

Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion [PDF]

Cellular and Molecular Life Sciences
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive ...
Klaus Ebnet, Michel Aurrand-Lions
doaj   +2 more sources

<i>AdhesionScore</i>: A Prognostic Predictor of Breast Cancer Patients Based on a Cell Adhesion-Associated Gene Signature. [PDF]

Cancers (Basel)
Esquível C, Ribeiro R, Ribeiro AS, Ferreira PG, Paredes J.   +4 more
europepmc   +3 more sources

Programming multicellular assembly with synthetic cell adhesion molecules

Nature, 2022
Synthetic cell adhesion molecules yield customized cell–cell interactions with adhesion properties that are similar to native interactions, and offer abilities for cell and tissue engineering and for systematically studying multicellular organization ...
Adam J. Stevens, A. Harris, Josiah Gerdts, Ki H. Kim, Coralie Trentesaux, Jonathan T. Ramirez, Wesley L. McKeithan, Faranak Fattahi, O. Klein, D. Fletcher, W. Lim   +10 more
semanticscholar   +1 more source

Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments

Communications Biology, 2023
CryoEM structures capture the initial α-catenin interaction with F-actin before the sensing of force.
Erumbi S. Rangarajan, Emmanuel W. Smith, Tina Izard   +2 more
doaj   +1 more source

miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion

Scientific Reports, 2021
The ability of integrins on the cell surface to mediate cell adhesion to the extracellular matrix ligands is regulated by intracellular signaling cascades.
Gideon Obeng, Eun Jeong Park, Michael G. Appiah, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +5 more
doaj   +1 more source

Irisin supports integrin-mediated cell adhesion of lymphocytes

Biochemistry and Biophysics Reports, 2021
Irisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expressed on mesenchymal cells, thereby playing an important role in the metabolic remodeling of the bone, skeletal muscle ...
Phyoe Kyawe Myint, Atsushi Ito, M.D., Michael G. Appiah, Gideon Obeng, Samuel Darkwah, Ph.D., Eiji Kawamoto, M.D., Ph.D., Arong Gaowa, Ph.D., Eun Jeong Park, Ph.D., Motomu Shimaoka, M.D., Ph.D.   +8 more
doaj   +1 more source

Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) have emerged as key players of intercellular communication and mediate crosstalk between tissues. Metastatic tumors release tumorigenic EVs, capable of pre-conditioning distal sites for organotropic metastasis.
Samuel Darkwah, Eun Jeong Park, Phyoe Kyawe Myint, Atsushi Ito, Atsushi Ito, Michael G. Appiah, Gideon Obeng, Eiji Kawamoto, Eiji Kawamoto, Motomu Shimaoka   +9 more
doaj   +1 more source

Cell–matrix adhesion [PDF]

Journal of Cellular Physiology, 2007
AbstractThe complex interactions of cells with extracellular matrix (ECM) play crucial roles in mediating and regulating many processes, including cell adhesion, migration, and signaling during morphogenesis, tissue homeostasis, wound healing, and tumorigenesis. Many of these interactions involve transmembrane integrin receptors.
Allison L, Berrier, Kenneth M, Yamada
openaire   +2 more sources

EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Nature Communications, 2021
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour   +8 more
doaj   +1 more source