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Junctional adhesion molecule-C: A multifunctional mediator of cell adhesion [PDF]

Cellular and Molecular Life Sciences
Junctional Adhesion Molecule-C (JAM-C) is a member of the JAM family of cell adhesion molecules. JAM-C is expressed by a large variety of tissues including epithelial and endothelial tissues, neuronal tissues, glial cells, cells of the reproductive ...
Klaus Ebnet, Michel Aurrand-Lions
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Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

Nature Communications, 2017
Cancer cells can disrupt cell-to-cell junctions, thus allowing migration and metastasis. Here starting from a chemical screening, Ito et al. reconstitute a step-by-step mechanism linking microtubule depolymerization and epithelial cell junction ...
Shoko Ito, Satoru Okuda, Masako Abe, Mari Fujimoto, Tetsuo Onuki, Tamako Nishimura, Masatoshi Takeichi   +6 more
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Criticality in Cell Adhesion [PDF]

Physical Review X, 2021
Version accepted for publication in Physical Review ...
Kristian Blom, Aljaž Godec
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Distinct inter-domain interactions of dimeric versus monomeric α-catenin link cell junctions to filaments

Communications Biology, 2023
CryoEM structures capture the initial α-catenin interaction with F-actin before the sensing of force.
Erumbi S. Rangarajan, Emmanuel W. Smith, Tina Izard   +2 more
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miRNA-200c-3p targets talin-1 to regulate integrin-mediated cell adhesion

Scientific Reports, 2021
The ability of integrins on the cell surface to mediate cell adhesion to the extracellular matrix ligands is regulated by intracellular signaling cascades.
Gideon Obeng, Eun Jeong Park, Michael G. Appiah, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka   +5 more
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Irisin supports integrin-mediated cell adhesion of lymphocytes

Biochemistry and Biophysics Reports, 2021
Irisin, a myokine released from skeletal muscle, has recently been found to act as a ligand for the integrins αVβ5, αVβ1, and α5β1 expressed on mesenchymal cells, thereby playing an important role in the metabolic remodeling of the bone, skeletal muscle ...
Phyoe Kyawe Myint, Atsushi Ito, M.D., Michael G. Appiah, Gideon Obeng, Samuel Darkwah, Ph.D., Eiji Kawamoto, M.D., Ph.D., Arong Gaowa, Ph.D., Eun Jeong Park, Ph.D., Motomu Shimaoka, M.D., Ph.D.   +8 more
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Cell Adhesion by Integrins [PDF]

Physiological Reviews, 2019
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions.
Michael Bachmann, Sampo Kukkurainen, Vesa P. Hytönen, Bernhard Wehrle-Haller   +3 more
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EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization

Nature Communications, 2021
The organization and force-generating property of actomyosin dictate the plasticity and behaviour of cells but the spatio-temporal regulation of this network is unclear.
Cécile Gaston, Simon De Beco, Bryant Doss, Meng Pan, Estelle Gauquelin, Joseph D’Alessandro, Chwee Teck Lim, Benoit Ladoux, Delphine Delacour   +8 more
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Potential Roles of Muscle-Derived Extracellular Vesicles in Remodeling Cellular Microenvironment: Proposed Implications of the Exercise-Induced Myokine, Irisin

Frontiers in Cell and Developmental Biology, 2021
Extracellular vesicles (EVs) have emerged as key players of intercellular communication and mediate crosstalk between tissues. Metastatic tumors release tumorigenic EVs, capable of pre-conditioning distal sites for organotropic metastasis.
Samuel Darkwah, Eun Jeong Park, Phyoe Kyawe Myint, Atsushi Ito, Atsushi Ito, Michael G. Appiah, Gideon Obeng, Eiji Kawamoto, Eiji Kawamoto, Motomu Shimaoka   +9 more
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The mitochondrial outer membrane protein SYNJ2BP interacts with the cell adhesion molecule TMIGD1 and can recruit it to mitochondria

BMC Molecular and Cell Biology, 2020
Background Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a recently identified cell adhesion molecule which is predominantly expressed by epithelial cells of the intestine and the kidney. Its expression is downregulated in both
Christian Hartmann, Ysabel Alessa Schwietzer, Daniel Kummer, Nils Kirschnick, Esther Hoppe, Eva-Maria Thüring, Mark Glaesner-Ebnet, Frauke Brinkmann, Volker Gerke, Stefan Reuter, Masanori Nakayama, Klaus Ebnet   +11 more
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