Results 71 to 80 of about 11,393,861 (364)

TOMM20 as a driver of cancer aggressiveness via oxidative phosphorylation, maintenance of a reduced state, and resistance to apoptosis

Molecular Oncology, EarlyView.
TOMM20 increases cancer aggressiveness by maintaining a reduced state with increased NADH and NADPH levels, oxidative phosphorylation (OXPHOS), and apoptosis resistance while reducing reactive oxygen species (ROS) levels. Conversely, CRISPR‐Cas9 knockdown of TOMM20 alters these cancer‐aggressive traits.
Ranakul Islam, Megan E. Roche, Zhao Lin, Diana Whitaker‐Menezes, Victor Diaz‐Barros, Eurico Serrano, Maria Paula Martinez Cantarin, Nancy J. Philp, Atrayee Basu Mallick, Ubaldo Martinez‐Outschoorn   +9 more
wiley   +1 more source

Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion.

Cell Motility and the Cytoskeleton, 2005
The morphology and cytoskeletal structure of fibroblasts, endothelial cells, and neutrophils are documented for cells cultured on surfaces with stiffness ranging from 2 to 55,000 Pa that have been laminated with fibronectin or collagen as adhesive ligand.
T. Yeung, Penelope C. Georges, L. Flanagan, B. Marg, Miguelina Ortiz, M. Funaki, Nastaran Zahir, W. Ming, V. Weaver, P. Janmey   +9 more
semanticscholar   +1 more source

Intercellular adhesion molecule-1

Journal of molecular medicine, 2020
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells.
A. Stolpe, P. V. D. Saag
semanticscholar   +1 more source

Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice

Scientific Reports, 2017
Mutations in the X-linked gene Protocadherin-19 (Pcdh19) cause female-limited epilepsy and mental retardation in humans. Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule, how its mutations bring about female-specific disorders ...
Shuichi Hayashi, Yoko Inoue, Satoko Hattori, Mari Kaneko, Go Shioi, Tsuyoshi Miyakawa, Masatoshi Takeichi   +6 more
doaj   +1 more source

The Rac3 GTPase in Neuronal Development, Neurodevelopmental Disorders, and Cancer

Cells, 2019
Rho family small guanosine triphosphatases (GTPases) are important regulators of the cytoskeleton, and are critical in many aspects of cellular and developmental biology, as well as in pathological processes such as intellectual disability and cancer. Of
Ivan de Curtis
doaj   +1 more source

Role of laminin and cognate receptors in cholangiocarcinoma cell migration

Cell Adhesion & Migration, 2021
Extensive desmoplasia in cholangiocarcinoma (CCA) is associated with tumor aggressiveness, indicating a need for further understanding of CCA cell–matrix interaction.
Kittiya Islam, Parichut Thummarati, Pakkanun Kaewkong, Banchob Sripa, Tuangporn Suthiphongchai   +4 more
doaj   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

Journal of Experimental Medicine, 2006
The chemokine stromal cell–derived factor (SDF-1; also known as chemokine ligand 12 [CXCL12]) regulates many essential biological processes, including cardiac and neuronal development, stem cell motility, neovascularization, angiogenesis, apoptosis, and ...
J. Burns, B. Summers, Yu Wang, A. Melikian, R. Berahovich, Z. Miao, M. Penfold, M. Sunshine, D. Littman, C. Kuo, Kevin Wei, B. Mcmaster, K. Wright, M. Howard, T. Schall   +14 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Critical Care Research and Practice, 2012
Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis ...
Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka   +3 more
doaj   +1 more source