Results 61 to 70 of about 5,944,904 (315)

L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]

, 2012
During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Carmen Grijota-Martinez (152374), Luis Garcia-Alonso, Sigrid Baars (152383), Cabedo, H, Emanuelle Donier, Carmen Grijota-Martinez, Gomez-Sanchez, JA, Lakomá, J, Emanuelle Donier (152367), Garcia-Alonso, L, Jose Antonio Gomez-Sanchez (152369), Jarmila Lakomá, Donier, E, Jarmila Lakomá (152379), Luis Garcia-Alonso (152388), Grijota-Martinez, C, Baars, S, Hugo Cabedo, Jose Antonio Gomez-Sanchez, Hugo Cabedo (152396), Sigrid Baars   +20 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration [PDF]

, 2015
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo.
Stramer, Brian M., Parsons, Maddy; id_orcid, Frame, Margaret, Bryan Serrels, Serrels, B, Parsons, M., Asier Jayo, Goult, B. T., Jayo, A., Zanet, J., Villari, G., Villari, G, Fitch, B., Serrels, Bryan, Stramer, BM, Fitch, Briana, Goult, Benjamin T., Frame, M., Jennifer Zanet, Frame, M, Jayo, Asier, Goult, Benjamin T, Goult, BT, Briana Fitch, Brian M. Stramer, Margaret Frame, Fitch, B, Stramer, B. M., Jayo, A, Zanet, Jennifer, Serrels, B., Maddy Parsons, Parsons, M, Giulia Villari, Zanet, J, Benjamin T. Goult, Villari, Giulia   +36 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Carbohydrate–carbohydrate interaction provides adhesion force and specificity for cellular recognition [PDF]

, 2004
© 2004 Bucior et al. This article is distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. The definitive version was published in Journal of Cell Biology 165 (2004): 529-537, doi:10.1083/jcb ...
Bucior, Iwona, Engel, A., Scheuring, Simon, Simon Scheuring, Burger, Max M., Burger, M. M., Scheuring, S., Iwona Bucior, Bucior, I., Max M. Burger, Andreas Engel, Engel, Andreas   +11 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Mycophenolate mofetil modulates adhesion receptors of the beta I integrin family on tumor cells: impact on tumor recurrence and malignancy [PDF]

, 2005
Background: Tumor development remains one of the major obstacles following organ transplantation. Immunosuppressive drugs such as cyclosporine and tacrolimus directly contribute to enhanced malignancy, whereas the influence of the novel compound ...
Natsheh Iyad, Blaheta Roman A, Müller Iris, Makarević Jasmina, Natsheh, Iyad Y. M., Müller, Iris, Beecken Wolf-Dietrich, Engl Tobias, Jonas Dietger, Jasmina Makarević, Wolf-Dietrich Beecken, Beecken, Wolf-Dietrich, Iris Müller, Relja Borna, Roman A Blaheta, Dietger Jonas, Blaheta, Roman A., Makarević, Jasmina, Tobias Engl, Iyad Natsheh, Jonas, Dietger, Borna Relja, Relja, Borna, Engl, Tobias A.   +23 more
core   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Junctional ER Organization Affects Mechanotransduction at Cadherin-Mediated Adhesions

Frontiers in Cell and Developmental Biology, 2021
Cadherin-mediated adhesions (also known as adherens junctions) are adhesive complexes that connect neighboring cells in a tissue. While the role of the actin cytoskeleton in withstanding tension at these sites of contact is well documented, little is ...
Michelle Joy-Immediato, Manuel J. Ramirez, Mauricio Cerda, Mauricio Cerda, Yusuke Toyama, Yusuke Toyama, Andrea Ravasio, Pakorn Kanchanawong, Pakorn Kanchanawong, Cristina Bertocchi   +9 more
doaj   +1 more source