Results 81 to 90 of about 780,002 (351)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension [PDF]

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) play critical roles in endothelial function and cardiovascular diseases.
Bizhan Hooshmand Moghadam, Shadi Moazamigoudarzi, Amir Rashidlamir, Babak Hooshmand-Moghadam   +3 more
doaj  

L-selectin and beta(2)-integrin expression on circulating bovine polymorphonuclear leukocytes during endotoxin mastitis [PDF]

, 2003
The aim of this in vivo study was to examine the effect of intramammarily administered endotoxin (lipopolysaccharide, LPS) on the expression of L-selectin (CD62L) and the beta(2)-integrin subunits CD11b and CD18 on circulating bovine PMN.
Burvenich, Christian, Diez Fraile, Araceli, Duchateau, Luc, Meyer, Evelyne   +3 more
core  

Ligand-Receptor Interactions

, 2008
The formation and dissociation of specific noncovalent interactions between a variety of macromolecules play a crucial role in the function of biological systems.
Alder B J, Alon R, Amit A G, André P, Antosiewicz J, Ashkin A, Atherton A, Atherton A, Balsera M, Beeson C, Bell G I, Bell G I, Berg H C, Berg H C, Bhat T N, Boland T, Bongrand P, Bongrand P, Brady G P, Brooks B R, Brune D, Brunk D K, Böhm H J, Böhm H J, Cantor C R, Capo C, Chesla S E, Chilkoti A, Choquet D, Chu L, Clackson T, Claesson P M, Collins F C, Connelly P R, Creighton T E, Creighton T E, Curtis A S G, Danmer U, Danmer U, Debye P, deLisi C, Dembo M, Dustin M L, Eisenberg D, Eisenberg D, Erlandsson R, Ermak D L, Evans E, Evans E, Evans E A, Evans E A, Evans E A, Evans E A, Evans E A, Eyring H, Eyring H, Fersht A, Florin E L, Gabdouline R R, Garboczi D N, Gilson M K, Goldsmith H L, Grubmüller H, Grutter M G, Hammer D A, Hammer D A, Helm C, Hill T L, Hirschefelder J O, Hoh J H, Honig B, Israelachvili J N, Israelachvili J N, Israelachvili J N, Izrailev S, Jencks W P, Jorgensen W L, Jorgensen W L, Kabat E A, Kaplanski G, Karplus M, Kishino A, Kozack R E, Kramers H A, Kuo S C, Kupfer A, Kwong D, Lawrence M B, Lawrence M B, Leckband D E, Leckband D E, Lee B, Lee C Y, Lee G U, Liebert R B, Lollo B A, London F, Maitland G C, Margenau H, Marston S B, Martorana V, McClay D R, McCloskey M A, Merkel R, Metropolis M, Meyhöfer E, Miyamoto S, Moy V T, Nishizaka T, Northrup S H, Northrup S H, Ooi T, Page M J, Palecek S P, Pangali C, Patel K D, Pauling L, Pierres A, Pierres A, Pierres A, Piper J W, Pratt L R, Richards F F, Richards F M, Rossky P J, Sato M, Schmid-Schöenbein G W, Schoup D, Schreiber G, Schuster P, Schwartz L, Smith S B, Sommerfeld A, Sommerfeld A, Steward M W, Stone S R, Stossel T P, Strick T R, Sturtevant J M, Szabo A, Szabo A, Szczesniak M M, Tees D F, Tha S P, Tsao Y H, Tulip W R, Vajda S, Valentine R C, van der Merwe P A, Vinckier A, von Andrian U H, von Fuchs, von Smoluchowski M, Voss Jr E W, Weast R C, Weber P C, Williams A-F, Winter C C, Wurmser R, Zurkhov S N   +159 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Molecular cloning and characterization of B-cadherin, a novel chick cadherin. [PDF]

, 1991
Calcium-dependent cell-cell adhesion is mediated in large part by a set of homologous integral membrane glycoproteins termed cadherins. In this report, antibodies to conserved domains in previously described cadherins have been used to isolate cDNAs ...
Napolitano, EW, Reichardt, LF, Venstrom, K, Wheeler, EF   +3 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Gender and age peculiarities of content changes of protein C, von Willebrand factor, vascular cell adhesion molecules sVCAM-1 in patients with acute left ventricle Q-wave myocardial infarction

Zaporožskij Medicinskij Žurnal, 2015
Markers of hemostasis have an influence on the state of postinfarction remodeling processes. Aim. In order to study the gender and age peculiarities, to determine the predictive value of the protein C, von Willebrand factor and vascular cell adhesion ...
S. M. Kyselov
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source