Results 71 to 80 of about 5,922,620 (255)

Dual implication of endothelial adhesion molecules in tumor progression and cancer immunity

Cell Adhesion & Migration
Adhesion molecules are proteins expressed at the surface of various cell types. Their main contribution to immunity is to allow the infiltration of immune cells in an inflamed site.
Louis-Emmanuel Chriqui, Sabrina Cavin, Jean Yannis Perentes   +2 more
doaj   +1 more source

Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion

Pharmaceutical Biology, 2020
Context Palmatine, a biologically active isoquinoline alkaloid, possesses multiple pharmaceutical activities against mucosal infection and inflammation.
Wang Hui, Yang Feng, Yan Baoqi, Dong Shuwei, Xin Ruihua, He Jiongjie, Cui Dongan, Sun Yan, Zhang Shidong, Yan Zuoting   +9 more
doaj   +1 more source

Mechanisms of Cell Adhesion Molecules in Endocrine-Related Cancers: A Concise Outlook

Frontiers in Endocrinology, 2022
Chemotherapy is a critical treatment for endocrine-related cancers; however, chemoresistance and disease recurrence remain a challenge. The interplay between cancer cells and the tumor microenvironment via cell adhesion molecules (CAMs) promotes drug ...
Yongsheng Ruan, Libai Chen, Danfeng Xie, Tingting Luo, Yiqi Xu, Tao Ye, Xiaona Chen, Xiaoqin Feng, Xuedong Wu   +8 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Adhesion molecules: a way to understand lupus

Rheumatology, 2022
Systemic lupus erythematosus is a connective disease in which all vitally important organs may be affected. The etiology of the disease is largely unknown and almost all immunological mechanisms have been proposed as the pathophysiological background of ...
Karolina Nowak, Olga Gumkowska-Sroka, Przemysław Kotyla   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Mycophenolate mofetil inhibits lymphocyte binding and the upregulation of adhesion molecules in acute rejection of rat kidney allografts. [PDF]

, 1996
Mycophenolate mofetil (MMF) interacts with purine metabolism and possibly with the expression of adhesion molecules. In the present study, we analysed the expression of these molecules in transplanted kidney allografts treated with RS LBNF1 kidneys were ...
Tilney, N., Schmid, C., Philipp, T., Hamar, Péter, Heemann, Uwe, Azuma, H.   +5 more
core   +2 more sources

Pathogenic Actions of Cell Adhesion Molecule 1 in Pulmonary Emphysema and Atopic Dermatitis

Frontiers in Cell and Developmental Biology, 2015
Cell adhesion mediated by adhesion molecules is of central importance in the maintenance of tissue homeostasis. Therefore, altered expression of adhesion molecules leads to the development of various tissue disorders involving cell activation ...
Azusa eYoneshige, Man eHagiyama, Mitsugu eFujita, Akihiko eIto   +3 more
doaj   +1 more source

Adhesion molecules in the stem cell niche - More than just staying in shape?

, 2010
The expression of adhesion molecules by stem cells within their niches is well described, but what is their function? A conventional view is that these adhesion molecules simply retain stem cells in the niche and thereby maintain its architecture and ...
Long, K., Kazanis, I., Marthiens, V., Moss, L., Ffrench-Constant, C.   +4 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source