Results 1 to 10 of about 21,323,950 (308)

ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo

Frontiers in Immunology, 2021
Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte
Deborah L W Chong, Jeremy Brown, Joanna Catherine Porter   +2 more
exaly   +3 more sources

Characterization of rat lung ICAM-1 [PDF]

Inflammation Research, 1998
We expressed soluble rat ICAM-1, generated a polyclonal anti-ICAM-1 antibody, and studied ICAM-1 upregulation in lung inflammatory conditions. Bacterial and baculovirus expression systems were employed.250 g adult, male Long Evans rats were used. For in vitro studies, rat pulmonary artery endothelial cells (RPAEC), rat alveolar macrophages and aortic ...
Schimmer, R. C., Beck-Schimmer, B., Ward, Peter A., Friedl, Hans P., Flory, C. M., Schmal, H., Pasch, T.   +6 more
openaire   +5 more sources

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. [PDF]

Journal of Clinical Investigation, 1996
This study examined the effectiveness of antisense oligonucleotides targeted to intercellular adhesion molecule-1 (ICAM-1) to inhibit endotoxin-induced upregulation of ICAM-1 and neutrophil emigration and compared the apparent role of ICAM-1 when examined using antisense oligonucleotides, anti-ICAM-1 antibodies, and ICAM-1 mutant mice.
T, Kumasaka, W M, Quinlan, N A, Doyle, T P, Condon, J, Sligh, F, Takei, A l, Beaudet, C F, Bennett, C M, Doerschuk   +8 more
openaire   +6 more sources

Regulation of ICAM-1 in human neutrophils [PDF]

Journal of Leukocyte Biology
Abstract Intercellular cell adhesion molecule 1 (ICAM-1) is a cell surface glycoprotein with a vital role in the immune response to pathogens. The expression pattern of ICAM-1 is wide ranging, encompassing endothelial cells, epithelial cells, and neutrophils. Recent work has characterized the role of ICAM-1 in murine neutrophils, but the
Vignarajah, Muralie, Wood, Alexander JT, Nelmes, Elizabeth, Subburayalu, Julien, Herre, Jurgen, Nourshargh, Sussan, Summers, Charlotte, Chilvers, Edwin R, Farahi, Neda   +8 more
core   +7 more sources

Role of ICAM-1 in triple-negative breast cancer [PDF]

Open Medicine
Intercellular adhesion molecule-1 (ICAM-1) is related to the occurrence and development of a variety of tumors. However, the role of ICAM-1 in the regulation of growth, metastasis, and clinical prognosis of the specific molecular subtypes of breast ...
Zhang Ying, Fan Jingjing, Wang Xiaoli, Wu Zhongyu, Ma Weiqiang, Ma Binlin   +5 more
doaj   +2 more sources

ICAM-1 does not inhibit NS5 RdRP activities. [PDF]

, 2023
(A-B) Denaturing PAGE analysis of the P2-to-P9 (A) and P2-to-P3 (B) conversion by DENV2 NS5 in the absence (Mock) or presence (ICAM-1) of ICAM-1. Left panels: Representative gel images. M: marker, a mixture of chemically synthesized 10-mer (5′-hydroxyl),
Ting Wang (16292), Zhongyuan Tan (5779016), Xianliang Ke (1945852), Zhenhua Zheng (1424308), Yan Liu (25061), Peng Gong (69507), Li Huang (107408), Jianhui Zhang (450305), Jiqin Wu (8790851), Jianping Tao (124288), Yuan Zhang (41832), Hanzhong Wang (127769)   +11 more
core   +1 more source

Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. [PDF]

PLoS ONE, 2010
BackgroundDuring transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukocytes.
Jaap D van Buul, Jos van Rijssel, Floris P J van Alphen, Mark Hoogenboezem, Simon Tol, Kees A Hoeben, Jan van Marle, Erik P J Mul, Peter L Hordijk   +8 more
doaj   +1 more source

Supplementary Data AC-ICAM [PDF]

, 2023
Supplementary data for the AC-ICAM ...
Michele Ceccarelli (7160081), Elad Ziv (11657557), Jessica Roelands (5751767), Julie Decock (547740), William Mifsud (11657538), Darawan Rinchai (11657551), Arun Rawat (11657530), Alexander Vahrmeijer (11657574), Peter J.K. Kuppen (9103737), Marc van den Eynde (11657553), Rosalyn Sayaman (8128410), Jérôme Galon (9103734), Mahir Abdulla Petkar (11657560), Wouter Hendrickx (401921), Franco Marincola (11657581), Rob Tollenaar (11657580), Damien Chaussabel (5827767), Ena Wang (11657576), Lance D. Miller (11657539), Mahmoud G Mohamed (11657550), Noel de Miranda (11657536), Souhaila Al Khodor (11657583), Fazulur Vempalli (11657541), Tatiana C. Carneiro-Lobo (11657522), Davide Bedognetti (9471254), Gabriele Zoppoli (11657568), Lotfi Chouchane (11657577), Gianni Monaco (3411857), Kun Wang (11657565), Amany Awad (11657533), Eiman Ahmed (11657542), Christophe Raynaud (11657544), Lisa Sara Mathew (11657563), Alberto Ballestrero (11657569), Parul Sing (11657520), Najeeb Syed (11657524), Stephan Lorenz (11657562), Khalid Fakhro (11657571), Shimaa Mohammed Sherif Khedr (11657547)   +38 more
core   +1 more source

ICAM-1: Isoforms and Phenotypes [PDF]

The Journal of Immunology, 2014
Abstract ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses ...
Theresa N, Ramos, Daniel C, Bullard, Scott R, Barnum   +2 more
openaire   +2 more sources

Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCα in human microvascular endothelial cells. [PDF]

PLoS ONE, 2012
ICAM-1-dependent leukocyte recruitment in vivo is inhibited by the vitamin E isoform d-α-tocopherol and elevated by d-γ-tocopherol. ICAM-1 is reported to activate endothelial cell signals including protein kinase C (PKC), but the PKC isoform and the ...
Hiam Abdala-Valencia, Sergejs Berdnikovs, Joan M Cook-Mills   +2 more
doaj   +1 more source