Results 11 to 20 of about 85,965 (264)

ICAM-1: Isoforms and Phenotypes [PDF]

The Journal of Immunology, 2014
Abstract ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses ...
Theresa N, Ramos, Daniel C, Bullard, Scott R, Barnum   +2 more
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Molecular Characterization and Expression Analysis of Intercellular Adhesion Molecule-1 (ICAM-1) Genes in Rainbow Trout (Oncorhynchus mykiss) in Response to Viral, Bacterial and Parasitic Challenge

Frontiers in Immunology, 2021
The intercellular adhesion molecule-1 (ICAM-1), known as CD54, is a transmembrane cell surface glycoprotein that interacts with two integrins (i.e., LFA-1 and Mac-l) important for trans-endothelial migration of leukocytes.
Xue Zhai, Wei-Guang Kong, Gao-Feng Cheng, Jia-Feng Cao, Fen Dong, Guang-Kun Han, Yan-Ling Song, Chuan-Jie Qin, Zhen Xu   +8 more
doaj   +1 more source

Characterization of rat lung ICAM-1 [PDF]

Inflammation Research, 1998
We expressed soluble rat ICAM-1, generated a polyclonal anti-ICAM-1 antibody, and studied ICAM-1 upregulation in lung inflammatory conditions. Bacterial and baculovirus expression systems were employed.250 g adult, male Long Evans rats were used. For in vitro studies, rat pulmonary artery endothelial cells (RPAEC), rat alveolar macrophages and aortic ...
Schimmer, R. C., Beck-Schimmer, B., Ward, Peter A., Friedl, Hans P., Flory, C. M., Schmal, H., Pasch, T.   +6 more
openaire   +3 more sources

Hyperglycemia Decreases Epithelial Cell Proliferation and Attenuates Neutrophil Activity by Reducing ICAM-1 and LFA-1 Expression Levels

Frontiers in Genetics, 2020
Delayed repair is a serious public health concern for diabetic populations. Intercellular adhesion molecule 1 (ICAM-1) and Lymphocyte function-associated antigen 1 (LFA-1) play important roles in orchestrating the repair process. However, little is known
Dongxu Qiu, Lei Zhang, Junkun Zhan, Qiong Yang, Hongliang Xiong, Weitong Hu, Qiao Ji, Jiabing Huang   +7 more
doaj   +1 more source

Intercellular adhesion molecule-1 augments myoblast adhesion and fusion through homophilic trans-interactions

Scientific Reports, 2017
The overall objective of the study was to identify mechanisms through which intercellular adhesion molecule-1 (ICAM-1) augments the adhesive and fusogenic properties of myogenic cells.
Francis X. Pizza, Ryan A. Martin, Evan M. Springer, Maxwell S. Leffler, Bryce R. Woelmer, Isaac J. Recker, Douglas W. Leaman   +6 more
doaj   +1 more source

Inflammation-Specific T Imaging Using Anti-Intercellular Adhesion Molecule 1 Antibody-Conjugated Gadolinium Diethylenetriaminepentaacetic Acid

Molecular Imaging, 2007
To examine inflammatory tissue, an initial and common symptom of various types of pathogenesis, we designed inflammation-targeted T 1 contrast agents prepared by bioconjugation of gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA) with anti ...
Kyu-Sil Choi, Sun-Hee Kim, Quan-Yu Cai, Soo-Yeon Kim, Hyang-Ok Kim, Hye-Jin Lee, Eun-A Kim, Seong-Eon Yoon, Ki-Jung Yun, Kwon-Ha Yoon   +9 more
doaj   +1 more source

Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells. [PDF]

PLoS ONE, 2012
Incorporation of intercellular adhesion molecule 1 (ICAM-1) into HIV-1 particles is known to markedly enhance the virus binding and infection of cells expressing lymphocyte function-associated antigen-1 (LFA-1). At the same time, ICAM-1 has been reported
Naoyuki Kondo, Gregory B Melikyan
doaj   +1 more source

Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. [PDF]

Journal of Clinical Investigation, 1996
This study examined the effectiveness of antisense oligonucleotides targeted to intercellular adhesion molecule-1 (ICAM-1) to inhibit endotoxin-induced upregulation of ICAM-1 and neutrophil emigration and compared the apparent role of ICAM-1 when examined using antisense oligonucleotides, anti-ICAM-1 antibodies, and ICAM-1 mutant mice.
T, Kumasaka, W M, Quinlan, N A, Doyle, T P, Condon, J, Sligh, F, Takei, A l, Beaudet, C F, Bennett, C M, Doerschuk   +8 more
openaire   +2 more sources

Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent

Journal of Nanobiotechnology, 2012
Background The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothelium of blood vessels in response to pro-inflammatory stimuli is of major importance for the regulation of local inflammation in cardiovascular diseases such as ...
Paulis Leonie EM, Jacobs Igor, van den Akker Nynke M, Geelen Tessa, Molin Daniel G, Starmans Lucas WE, Nicolay Klaas, Strijkers Gustav J   +7 more
doaj   +1 more source

Failure to block adhesion of Plasmodium falciparum-infected erythrocytes to ICAM-1 with soluble ICAM-1 [PDF]

Infection and Immunity, 1997
The adhesion of Plasmodium falciparum-infected erythrocytes is thought to play a central role in the pathogenesis of severe malaria. ICAM-1 has been identified as one of the host receptors for parasitized erythrocytes and has been implicated as being involved in progression to cerebral malaria.
Craig, A, Pinches, R, Khan, S, Roberts, D, Turner, G, Newbold, C, Berendt, A   +6 more
openaire   +3 more sources