Results 31 to 40 of about 21,323,950 (308)

ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells

Stem Cell Reports, 2018
Summary: The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, the molecular events in the HSC niche remain to be investigated. Here, we report that
Yu-feng Liu, Shao-ying Zhang, Ying-ying Chen, Kun Shi, Bin Zou, Jun Liu, Qiong Yang, Hua Jiang, Lai Wei, Chang-zheng Li, Meng Zhao, Dmitry I. Gabrilovich, Hui Zhang, Jie Zhou   +13 more
doaj   +1 more source

Comprehensive analysis of lymph node stroma-expressed Ig superfamily members reveals redundant and nonredundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing [PDF]

, 2010
Although it is well established that stromal intercellular adhesion molecule-1 (ICAM-1), ICAM-2, and vascular cell adhesion molecule-1 (VCAM-1) mediate lymphocyte recruitment into peripheral lymph nodes (PLNs), their precise contributions to the ...
Mellado, Mario, Boscacci, Rémy T, Checa Sevilla, Ana Isabel, Natale, Daniela, Henrickson, Sarah, Engelhardt, Britta, Deutsch, Urban, Pfeiffer, Friederike, Gollmer, Kathrin, Stein, Jens V, Fukui, Yoshinori, Soriano, Silvia Fernandez, von Andrian, Ulrich H, Martin, Ana Maria   +13 more
core   +1 more source

Failure to block adhesion of Plasmodium falciparum-infected erythrocytes to ICAM-1 with soluble ICAM-1 [PDF]

Infection and Immunity, 1997
The adhesion of Plasmodium falciparum-infected erythrocytes is thought to play a central role in the pathogenesis of severe malaria. ICAM-1 has been identified as one of the host receptors for parasitized erythrocytes and has been implicated as being involved in progression to cerebral malaria.
Craig, A, Pinches, R, Khan, S, Roberts, D, Turner, G, Newbold, C, Berendt, A   +6 more
openaire   +3 more sources

β2 integrin-mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood-brain barrier [PDF]

, 2014
In acute neuroinflammatory states such as meningitis, neutrophils cross the blood-brain barrier (BBB) and contribute to pathological alterations of cerebral function. The mechanisms that govern neutrophil migration across the BBB are ill defined.
Vestweber, Dietmar, Lyck, Ruth, Engelhardt, Britta, Gorina Mendiz, Roser   +3 more
core   +1 more source

Targeting of ICAM-1 on vascular endothelium under static and shear stress conditions using a liposomal Gd-based MRI contrast agent

Journal of Nanobiotechnology, 2012
Background The upregulation of intercellular adhesion molecule-1 (ICAM-1) on the endothelium of blood vessels in response to pro-inflammatory stimuli is of major importance for the regulation of local inflammation in cardiovascular diseases such as ...
Paulis Leonie EM, Jacobs Igor, van den Akker Nynke M, Geelen Tessa, Molin Daniel G, Starmans Lucas WE, Nicolay Klaas, Strijkers Gustav J   +7 more
doaj   +1 more source

ICAM‐1‐targeted nanocarriers attenuate endothelial release of soluble ICAM‐1, an inflammatory regulator [PDF]

Bioengineering & Translational Medicine, 2017
AbstractTargeting of drug nanocarriers (NCs) to intercellular adhesion molecule‐1 (ICAM‐1), an endothelial‐surface protein overexpressed in many pathologies, has shown promise for therapeutic delivery into and across this lining. However, due to the role of ICAM‐1 in inflammation, the effects of targeting this receptor need investigation.
Manthe, Rachel L., Muro, Silvia
openaire   +2 more sources

Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. [PDF]

, 2012
BACKGROUND: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria.
Cox-Singh, J, Craig, Alister G., Lu Woon, Alister G Craig, Farrah A Fatih, Woon, Lu Chan, Siner, Angela, Singh Balbir, Cox-Singh, Janet, Siner Angela, Fatih, FA, Singh, Balbir, Janet Cox-Singh, Singh, B, Balbir Singh, Fatih, Farrah A., Cox-Singh Janet, Krishna Sanjeev, Ahmed, Atique, Siner, A, Angela Siner, Cox Singh, Janet, Ahmed Atique, Craig Alister G, Woon, LC, Woon Lu, Krishna, S, Fatih Farrah A, Sanjeev Krishna, Craig, AG, Krishna, Sanjeev, Ahmed, A, Craig, Alister, Atique Ahmed, Lu Chan Woon   +34 more
core   +1 more source

ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer

Cell Death and Disease, 2022
Colorectal cancer (CRC) has a 5-year survival rate of
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee   +4 more
doaj   +1 more source

Characterization of the murine Icam-1 gene

Genomics, 1992
Intercellular adhesion molecule-1 (ICAM-1, CD54) is a cell adhesion molecule that interacts with the leukocyte beta 2 integrins, LFA-1 and Mac-1. Murine inflammatory models are being utilized increasingly to define the role that ICAM-1 induction plays in the initiation of inflammation. We have isolated murine genomic clones that contain the Icam-1 gene
C M, Ballantyne, J E, Sligh, X Y, Dai, A L, Beaudet   +3 more
openaire   +2 more sources

Serum levels of s-TM s-ICAM-1 and s-VCAM-1 were detected to evaluate endothelial injury in vivo. [PDF]

, 2017
Values are means ± SD (n = 3). (A) The concentration of s-TM increased about 3 times in EMPs treated group compared with the normal control group. (B) The level of s-VCAM-1 was ng/ml in EMPs treated group and ng/ml in normal control group.
Jiajun Xu (510477), Kun Zhang (108291), Weigang Xu (297927), Guoyang Huang (297924), Long Qing (699364), Xuhua Yu (3692524), Wenwu Liu (297923)   +6 more
core   +1 more source