Results 81 to 90 of about 5,922,620 (255)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Gender and age peculiarities of content changes of protein C, von Willebrand factor, vascular cell adhesion molecules sVCAM-1 in patients with acute left ventricle Q-wave myocardial infarction

Zaporožskij Medicinskij Žurnal, 2015
Markers of hemostasis have an influence on the state of postinfarction remodeling processes. Aim. In order to study the gender and age peculiarities, to determine the predictive value of the protein C, von Willebrand factor and vascular cell adhesion ...
S. M. Kyselov
doaj   +1 more source

Quantitative investigation of calcimimetic R568 on beta cell adhesion and mechanics using AFM single-cell force spectroscopy [PDF]

, 2014
In this study we use a novel approach to quantitatively investigate mechanical and interfacial properties of clonal β-cells using AFM-Single Cell Force Spectroscopy (SCFS). MIN6 cells were incubated for 48hrs with 0.5mM Ca2+ ± the calcimimetic R568 (1μM).
Younis, Mustafa Y.G., Hills, Claire E., Younis, Mustafa Y. G., Squires, Paul E., Liu, Kuo-Kang, Siamantouras, Eleftherios   +5 more
core   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Evaluation of serum levels of cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) following a resistance training program in middle-aged and elderly men with hypertension [PDF]

مجله علوم پزشکی فیض (پیوسته)
Background and Aim: Cell adhesion molecules (ICAM-1) and vascular adhesion molecules (VCAM-1) play critical roles in endothelial function and cardiovascular diseases.
Bizhan Hooshmand Moghadam, Shadi Moazamigoudarzi, Amir Rashidlamir, Babak Hooshmand-Moghadam   +3 more
doaj  

Cell Adhesion Molecules and Protein Synthesis Regulation in Neurons

Frontiers in Molecular Neuroscience, 2020
Cell adhesion molecules (CAMs) mediate interactions of neurons with the extracellular environment by forming adhesive bonds with CAMs on adjacent membranes or via binding to proteins of the extracellular matrix.
Irina Kozlova, Saroj Sah, Ryan Keable, Iryna Leshchyns’ka, Michael Janitz, Vladimir Sytnyk   +5 more
doaj   +1 more source

Adhesion molecule-dependent mechanisms regulate the rate of macrophage clearance during the resolution of peritoneal inflammation [PDF]

, 2002
Macrophage clearance is essential for the resolution of inflammation. Much is known about how monocytes enter the inflammatory site but little is known about how resultant macrophages are cleared. We have previously demonstrated that macrophage clearance
Mutsaers, SE, Bottoms, S, Cooksley, H, Helen Cauldwell, Bellingan, GJ, Christopher Haslett, Xu, P, Haslett, C, Geoffrey John Laurent, Steven Eugene Mutsaers, Anthony Shock, Laurent, GJ, Ping Xu, Stephen Bottoms, Cauldwell, H, Shock, A, Helen Cooksley, Geoffrey John Bellingan   +17 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source