Results 91 to 100 of about 2,149,730 (295)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Dense blocks of energetic ions driven by multi-petawatt lasers [PDF]

, 2016
Laser-driven ion accelerators have the advantages of compact size, high density, and short bunch duration over conventional accelerators. Nevertheless, it is still challenging to simultaneously enhance the yield and quality of laser-driven ion beams for ...
Chen, M., Liu, M., Murakami, M., Sheng, Z. M., Weng, S. M., Yu, L. L., Zhang, J.   +6 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Tumor cell representation by an improvised technique of fine-needle aspiration specimen acquisition and cell block preparation: Our experience in lung cancer cases in a peripheral center of eastern India

Journal of Cytology, 2020
Background: Being a minimally invasive diagnostic technique, Fine-Needle Aspiration Cytology (FNAC) has become the first-line test and corresponding aspirated material has become the target specimen for diagnosis and ancillary tests in lung carcinoma ...
Anup Kr Boler, Shreosee Roy, Arghya Bandyopadhyay, Abhishek Bandyopadhyay, Mrinal Kanti Ghosh   +4 more
doaj   +1 more source

Phases of the infinite U Hubbard model

, 2011
We apply the density matrix renormalization group (DMRG) to study the phase diagram of the infinite U Hubbard model on 2-, 4-, and 6-leg ladders. Where the results are largely insensitive to the ladder width, we consider the results representative of the
C.-C. Chang, D. J. Scalapino, Erez Berg, H. Yao, Hong Yao, Li Liu, Steven A. Kivelson, Steven R. White   +7 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Indian academy of cytologists guidelines for collection, preparation, interpretation, and reporting of serous effusion fluid samples

Journal of Cytology, 2020
Cytological examination plays an important role in the initial work-up of the serous cavity effusion fluids to find out the possible etiology as benign or malignant.
Radhika Srinivasan, Bharat Rekhi, Arvind Rajwanshi, Saleem Pathuthara, Sandeep Mathur, Deepali Jain, Nalini Gupta, Upasana Gautam, Naresh Rai, Vijay Shrawan Nijhawan, Venkat Iyer, Pranab Dey, Prabal Deb, Dev Prasoon   +13 more
doaj   +1 more source

On the limiting Markov process of energy exchanges in a rarely interacting ball-piston gas

, 2016
We analyse the process of energy exchanges generated by the elastic collisions between a point-particle, confined to a two-dimensional cell with convex boundaries, and a `piston', i.e.
Bálint, Péter, Gilbert, Thomas, Nándori, Péter, Szász, Domokos, Tóth, Imre Péter   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Clinicopathological study of serous effusions - Comparison between conventional smear and cell block technique: A cross-sectional study

Journal of Clinical Sciences
Background: Serous effusions are a common clinical finding in various pathological conditions, and cytological examination plays a crucial role in determining their etiology.
Shirish S. Chandanwale, Ranjana Roy, Madhuri Singh, Akshi Raj, Abhishek Tambile   +4 more
doaj   +1 more source