Results 61 to 70 of about 599,411 (264)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Role of extracellular vesicles in cancer: implications in immunotherapeutic resistance

Frontiers in Immunology
Extracellular vesicles (EVs) are lipid membrane-bound vesicles involved in cell-cell communication, particularly in the context of cancer. Immunotherapy, a rapidly evolving field in oncology, is a type of cancer treatment relying on the body’s own immune
Shuai Wang, Zerui Wang, Min Liu, Xiyang Sun   +3 more
doaj   +1 more source

Cell–cell communication during collective migration [PDF]

Proceedings of the National Academy of Sciences, 2016
Cell motility plays a critical role in many biological and medical processes, including wound healing, morphogenesis, and cancer metastasis (1). Often, this movement is guided by external chemical cues in the form of chemoattractant gradients. These cues consist of diffusive chemoattractant molecules that bind to surface receptors on the cell membrane ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Editorial: Cell Communication in Vascular Biology

Frontiers in Physiology, 2021
Mauricio P. Boric, Walter N. Durán, Xavier F. Figueroa   +2 more
doaj   +1 more source

Controlled Construction of Stable Network Structure Composed of Honeycomb-Shaped Microhydrogels

Life, 2018
Recently, the construction of models for multicellular systems such as tissues has been attracting great interest. These model systems are expected to reproduce a cell communication network and provide insight into complicated functions in living systems.
Masayuki Hayakawa, Satoshi Umeyama, Ken H. Nagai, Hiroaki Onoe, Masahiro Takinoue   +4 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Single-Cell Immune Characteristics Of Periodontitis And Pss

International Dental Journal
Aim or purpose: Conduct a comprehensive and high-resolution analysis and comparison of the immune cell blueprints in periodontitis (PD) and primary Sjögren's syndrome (pSS), to reveal the similarities and differences between the two diseases at the ...
Juanjuan Li, Chuhua Tang, Chunfang Wang, Yuhui Chen, Jinyang Yu, Qianyu Yang, Yan Liu   +6 more
doaj   +1 more source

Cell–Cell Mechanical Communication in Cancer

Cellular and Molecular Bioengineering, 2018
Communication between cancer cells enables cancer progression and metastasis. While cell-cell communication in cancer has primarily been examined through chemical mechanisms, recent evidence suggests that mechanical communication through cell-cell junctions and cell-ECM linkages is also an important mediator of cancer progression.
Samantha C. Schwager, Paul V. Taufalele, Cynthia A. Reinhart-King   +2 more
openaire   +3 more sources