Results 91 to 100 of about 13,207,162 (409)

White blood cells and coronary heart disease: A mendelian randomization study

open access: yesFrontiers in Genetics, 2023
Background: The causal direction and magnitude of the associations between blood cell count and coronary heart disease (CHD) remain uncertain due to susceptibility of reverse causation and confounding.
Qiuping Zhao   +5 more
doaj   +1 more source

DeGPR: Deep Guided Posterior Regularization for Multi-Class Cell Detection and Counting [PDF]

open access: yesarXiv, 2023
Multi-class cell detection and counting is an essential task for many pathological diagnoses. Manual counting is tedious and often leads to inter-observer variations among pathologists. While there exist multiple, general-purpose, deep learning-based object detection and counting methods, they may not readily transfer to detecting and counting cells in
arxiv  

A Guided Spatial Transformer Network for Histology Cell Differentiation [PDF]

open access: yesEG VCBM 2017 Proceedings, 2017
Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic figures, retrieving annotation data for sufficient statistics is a tedious task and prone to a significant error ...
arxiv   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

open access: yesFEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang   +2 more
wiley   +1 more source

Differential cell count as an alternative method to diagnose dairy cow mastitis.

open access: yesJournal of Dairy Science, 2013
Changes in relative cell proportions occurring in diseased mammary glands of dairy cows can be determined using differential cell count (DCC). The present study was carried out in 2 consecutive trials, with 2 goals: (a) to test the consistency of DCC ...
Rachel Pilla   +6 more
semanticscholar   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

open access: yesFEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre   +4 more
wiley   +1 more source

Nonparametric Bayesian Two-Level Clustering for Subject-Level Single-Cell Expression Data [PDF]

open access: yes, 2019
The advent of single-cell sequencing opens new avenues for personalized treatment. In this paper, we address a two-level clustering problem of simultaneous subject subgroup discovery (subject level) and cell type detection (cell level) for single-cell expression data from multiple subjects.
arxiv   +1 more source

Negative binomial count splitting for single-cell RNA sequencing data [PDF]

open access: yesarXiv, 2023
The analysis of single-cell RNA sequencing (scRNA-seq) data often involves fitting a latent variable model to learn a low-dimensional representation for the cells. Validating such a model poses a major challenge. If we could sequence the same set of cells twice, we could use one dataset to fit a latent variable model and the other to validate it.
arxiv  

A systematic review and meta-regression of temporal trends in adult CD4(+) cell count at presentation to HIV care, 1992-2011.

open access: yesClinical Infectious Diseases, 2013
BACKGROUND The clinical status of human immunodeficiency virus (HIV)-positive persons at the time of presentation to medical care has important individual- and population-level implications.
C. Lesko   +4 more
semanticscholar   +1 more source

Impact of policy-induced structural change on milk quality : evidence from the Flemish dairy sector [PDF]

open access: yes, 2009
This paper uses a Markov chain model to analyse the dynamics in farm size distribution among the Flemish dairy sector and the impact of quota policy regulation on such changes.
Buysse, Jeroen   +3 more
core   +2 more sources

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