Results 91 to 100 of about 10,542,794 (310)

Notch promotes neural lineage entry by pluripotent embryonic stem cells [PDF]

, 2006
A central challenge in embryonic stem (ES) cell biology is to understand how to impose direction on primary lineage commitment. In basal culture conditions, the majority of ES cells convert asynchronously into neural cells.
Smith, Austin G, Austin G Smith, Heavey Barry, Alexandra Benchoua, Benchoua, Alexandra, Smith, Austin,, Benchoua Alexandra, Sally Lowell, Smith Austin G, Lowell, Sally; id_orcid, Smith, Austin, G., Lowell Sally, Lowell, Sally, Heavey, Barry, Barry Heavey   +14 more
core   +1 more source

Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells

Journal of Pharmacological Sciences, 2009
Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer.
Neetu Singh, Manisha Nigam, Vishal Ranjan, Ramesh Sharma, Anil Kumar Balapure, Srikanta Kumar Rath   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

1H NMR Spectroscopy Profiling of Metabolic Reprogramming of Chinese Hamster Ovary Cells upon a Temperature Shift during Culture [PDF]

, 2013
We report an NMR based approach to determine the metabolic reprogramming of Chinese hamster ovary cells upon a temperature shift during culture by investigating the extracellular cell culture media and intracellular metabolome of CHOK1 and CHO-S cells ...
Mark J. Howard (443860), C Mark Smales, Masterton, Rosalyn J., Howard, Mark J., Jane L. Wagstaff (469296), Jane F. Povey (469298), Wagstaff, Jane L., Smales, Christopher Mark, C. Mark Smales (128831), Povey, Jane F., Jane L Wagstaff, Rosalyn J Masterton, Rosalyn J. Masterton (469297), Mark J Howard, Jane F Povey   +14 more
core   +1 more source

Cell culture engineering: part 2 [Frontiers of biomedical engineering ]

, 2011
Educação Superior::Ciências Biológicas::Biologia GeralEducação Superior::Ciências Biológicas::BioquímicaEducação Superior::Engenharias::Engenharia BiomédicaPresents the lecture by Professor Saltzman.
Saltzman, W. Mark
core   +1 more source

Bioreactor-Based Liquid Culture and Production of Konjac Micro-Corm

Horticulturae
Konjac (Amorphophallus konjac K. Koch) has numerous health benefits, but traditional propagation is hindered by long growth periods and soil-borne diseases. This study developed a novel cell liquid culture system to directly produce micro-corms of konjac
Yuqi Sun, Xian Sun, Yufan Pan, Changbin Liu, Lingye Su, Zongshen Zhang   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

ManNAc attenuates Man5 glycoform abundance through GNE-mediated metabolic channeling of UDP-GlcNAc to N-glycosylation modifications via CMP-Neu5Ac biosynthesis

mAbs
N-glycosylation, a critical quality attribute of monoclonal antibodies, plays a pivotal role in regulating pharmacokinetics and pharmacodynamics through high-mannose (Man5) glycoform modulation.
Ruiqiang Sun, Miaomiao Chai, Jiahao Man, Guiju Yang, Hai Shu, Qiancheng Wang, Cong Tian, Linlin Wang, Shanhui Liao, Yifeng Zhang, Yanyan Cao, Lisha Xia, Haili Yang, Ting Zhang, Luoyan Ma, Shenwang Cao, Qiao Gao, Yichen Le, Mingli Shi, Quanxue Li, Yinmao Fan, Hang Zhou   +21 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source