Results 51 to 60 of about 17,041,985 (363)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Two Decades of Global Progress in Authorized Advanced Therapy Medicinal Products: An Emerging Revolution in Therapeutic Strategies

Frontiers in Cell and Developmental Biology, 2020
The introduction of advanced therapy medicinal products (ATMPs) to the global pharma market has been revolutionizing the pharmaceutical industry and has opened new routes for treating various types of cancers and incurable diseases.
Roya Ramezankhani, Roya Ramezankhani, Shukoofeh Torabi, Shukoofeh Torabi, Neda Minaei, Neda Minaei, Hoda Madani, Hoda Madani, Siamak Rezaeiani, Siamak Rezaeiani, Seyedeh Nafiseh Hassani, Seyedeh Nafiseh Hassani, Adrian P. Gee, Massimo Dominici, Daniela Nascimento Silva, Daniela Nascimento Silva, Hossein Baharvand, Hossein Baharvand, Hossein Baharvand, Ensiyeh Hajizadeh-Saffar, Ensiyeh Hajizadeh-Saffar, Ensiyeh Hajizadeh-Saffar   +21 more
doaj   +1 more source

Characterizing steady states of genome-scale metabolic networks in continuous cell cultures

, 2017
We present a model for continuous cell culture coupling intra-cellular metabolism to extracellular variables describing the state of the bioreactor, taking into account the growth capacity of the cell and the impact of toxic byproduct accumulation.
Fernandez-de-Cossio-Diaz, Jorge, León, Kalet, Mulet, Roberto   +2 more
core   +3 more sources

Modifications at the C-Terminus To Improve Pyrrole−Imidazole Polyamide Activity in Cell Culture [PDF]

, 2009
Pyrrole−imidazole (Py-Im) hairpin polyamides are a class of small molecule DNA minor groove binding compounds that have been shown to modulate endogenous gene expression in cell culture.
Dervan, Peter B., Jacobs, Claire S.
core   +2 more sources

Evidence-based guidelines for controlling pH in mammalian live-cell culture systems

Communications Biology, 2019
A fundamental variable in culture medium is its pH, which must be controlled by an appropriately formulated buffering regime, since biological processes are exquisitely sensitive to acid–base chemistry.
J. Michl, K. Park, P. Swietach
semanticscholar   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

FOXO3a/PI3K/Akt pathway participates in the ROS- induced apoptosis triggered by α-ZEL and β-ZEL

Scientific Reports
Zearalenone (ZEN), an estrogenic mycotoxin, is one of the most common food and feed contaminants. Also, its metabolites α-zearalenol (α-ZEL) and β-zearalenol (β-ZEL) are considered to induce oxidative stress, however its effect in prostate cells is not ...
Dominika Ewa Habrowska-Górczyńska, Marta Justyna Kozieł, Kinga Anna Urbanek, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska   +4 more
doaj   +1 more source

Extracellular matrix of lung scaffolds submitted to different means of sterilization: a systematic review [version 1; peer review: 1 approved, 2 approved with reservations]

F1000Research
Chronic respiratory diseases often necessitate lung transplantation due to irreversible damage. Organ engineering offers hope through stem cell-based organ generation. However, the crucial sterilization step in scaffold preparation poses challenges. This
Luis Vicente Franco Oliveira, Giuseppe Insalaco, Renata K. Palma, Rodolfo P. Vieira, Deise A. A. P. Oliveira, Rodrigo F. Oliveira, Iransé Oliveira-Silva, Miria C. Oliveira, Diego A. C. P. G. Mello, Andressa D. Cereta, Adriano L. Fonseca, Joao Pedro R. Afonso, Ricardo S. Moura   +12 more
doaj   +1 more source

Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells

Cells, 2021
Mesenchymal stem cells (MSCs) are of great interest for their use in cell-based therapies due to their multipotent differentiation and immunomodulatory capacities.
Ilias Nikolits, Sabrina Nebel, Dominik Egger, Sebastian Kreß, Cornelia Kasper   +4 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source