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INTRODUCTION: Glioblastoma multiforme (GBM) is one of the most common and deadliest primary brain tumors. Despite standard treatments such as surgical resection, radiation, and high-dose chemotherapy, the average survival time of patients after diagnosis
Mehmet Eşref Alkış
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3D Cell Culture—Can It Be As Popular as 2D Cell Culture?
A 2D cell culture, a technology used for a long time in the field of life sciences, refers to the growth of cells on a flat surface. The application of this technology enables humans to study the physiological and pathological activities of cells in ...
Miao Sun +7 more
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Recent Advances in Three-Dimensional Stem Cell Culture Systems and Applications
Cell culture is one of the most core and fundamental techniques employed in the fields of biology and medicine. At present, although the two-dimensional cell culture method is commonly used in vitro, it is quite different from the cell growth ...
Xiaowen Wu +4 more
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Background: Squamous cell carcinoma (SCC) is the most common oral malignancy with high rate of mortality. Cisplatin, as the most effective chemotherapy drug, has side effects.
Fatima Bijani +5 more
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Inadequacy of most animal models for drug efficacy assessments has led to the development of improved in vitro models capable of mimicking in vivo exposure scenarios.
Hadi Hashemzadeh +5 more
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Optimized Primary Culture and Subculture of Granulosa Cells
Background: Primordial follicle includes an oocyte surrounded by a layer of somatic cells called Granulosa Cells (GCs). GCs, also known as nurse cells, are an important protective element for the growth and survival of oocytes.
Nadia Fallah +4 more
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An Modified Primary Culture Method of Breast Cancer-associated Fibroblasts
Objective To establish a rapid and high efficient method of primary culture of BCAFs by improving primary culture methods of common breast cancer-associated fibroblasts (BCAFs).
LI Zhiyong, BAI Xue, CAI Huiyun
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Human embryonic stem cell-derived mesenchymal progenitor (hES-MP) cells are mesenchymal-like cells, derived from human embryonic stem cells without the aid of feeder cells. They have been suggested as a potential alternative to mesenchymal stromal cells (
Sandra M. Jonsdottir-Buch +2 more
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Memantine protects the cultured rat hippocampal neurons treated by NMDA and amyloid β1–42
Alzheimer’s disease (AD) is a devastating neurodegenerative condition with no effective treatments. Recent research highlights the role of NMDA receptors in AD development, as excessive activation of these receptors triggers excitotoxicity. Memantine, an
Nataliia M. Rozumna +2 more
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Evaluation of a composite skin substitute to treat venous stasis ulcers: a pilot study
Introduction: Venous leg ulcers represent a therapeutic challenge, and they are associated to significant morbidity and cost. Many advances have been made to develop and apply biological skin substitutes, showing they can be beneficial for patients with
Paula Dadalti-Granja +7 more
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