Results 291 to 300 of about 2,740,660 (385)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Mastering Organoid Growth: A Complete Guide to Overcoming Methodological Challenges. [PDF]

MedComm (2020)
Jiao C, Karakaya OF, Dadgar N, Wehrle CJ, Massoud Z, Hong H, Fairchild RL, Leipzig N, Aucejo F, Ma WW, Melenhorst JJ, Gonzales SF, Schlegel A.   +12 more
europepmc   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Application of spectroscopic methods for direct characterization of photosynthetic pigments and inert intracellular components in the model purple non sulfur bacterium Rhodospirillum rubrum. [PDF]

Microb Cell Fact
Slaninova E, Pacasova VA, Samek O, Fleuriot-Blitman H, Zinn M, Koller M, Benesova M, Obruca S, Sedlacek P.   +8 more
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Donor DNA: Embedding self-regulation into blood donation culture. [PDF]

Hematol Transfus Cell Ther
Sinha DR.
europepmc   +1 more source

Multifunctional Microstructured Surfaces by Microcontact Printing of Reactive Microgels

Advanced Functional Materials, EarlyView.
Reactive poly(N‐vinylcaprolactam‐co‐glycidyl methacrylate) microgels are used as functional inks to create surface‐grafted arrays on glass via microcontact printing. The patterns (10–50 µm widths and spacings) enable stable binding and post‐functionalization with dyes and peptides.
Inga Litzen, Alexander Töpel, Martin Zenke, Antonio Sechi, Andrij Pich   +4 more
wiley   +1 more source

Synergizing biomaterials and cellular molecular pathways: a new frontier in hair follicle generation. [PDF]

J Transl Med
Bajouri A, Aghdami N, Nilforoushzadeh MA.   +2 more
europepmc   +1 more source

Next-Gen Stroke Models: The Promise of Assembloids and Organ-on-a-Chip Systems. [PDF]

Cells
Lombardozzi G, Szebényi K, Giorgi C, Topi S, d'Angelo M, Castelli V, Cimini A.   +6 more
europepmc   +1 more source