Results 41 to 50 of about 1,114,098 (265)

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Enhanced physicochemical and biological properties of ion-implanted Titanium using Electron Cyclotron Resonance ion sources [PDF]

, 2016
The surface properties of metallic implants play an important role in their clinical success. Improving upon the inherent shortcomings of Ti implants, such as poor bioactivity, is imperative for achieving clinical use.
Biri, Sándor, Csik, Attila, Ding, Shinn-Jyh, Hegedüs Csaba (1953-) (fogszakorvos), Hegedűs, Csaba, Ho, Chia-Che   +5 more
core   +3 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Plant cell packs: a scalable platform for recombinant protein production and metabolic engineering [PDF]

, 2019
Industrial plant biotechnology applications include the production of sustainable fuels, complex metabolites and recombinant proteins, but process development can be impaired by a lack of reliable and scalable screening methods. Here, we describe a rapid
Arfi, Bendandi, Buyel, Buyel, Buyel, Buyel, Buyel, Buyel, Fradkov, Geli, Goojani, Holland, Howat, Kingsbury, Matz, Munro, Muster, Noe, Pennings, Piotrzkowski, Prasher, Sangwan, Simmons, Spiegel, Staniek, Trkola, Turpen, Wong, Zhong   +28 more
core   +1 more source

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Automated Motion Analysis of Adherent Cells in Monolayer Culture [PDF]

, 2015
This paper presents a novel method for tracking and characterizing adherent cells in monolayer culture. A system of cell tracking employing computer vision techniques was applied to time-lapse videos of replicate normal human uro-epithelial cell cultures
Bedder, M., Shabir, S., Smith, S.L., Southgate, J., Walker, D., Zhang, Z.   +5 more
core   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Lectin based glycoprotein analysis [PDF]

, 2008
Many of the biopharmaceutical therapeutics entering the market and currently in clinical trails are recombinant glycoprotein molecules, the glycan moieties of which have a significant impact on efficacy and immunogenicity.
Clarke, Paul A., Goel, Alok, O'Connell, Michael, O'Connor, Brendan, Thompson, Roisin   +4 more
core  

Phenotypic Variation and Bistable Switching in Bacteria [PDF]

, 2008
Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions.
A Becskei, A Becskei, A Guerrero, A Johnson, A Khlebnikov, A Khlebnikov, A Khlebnikov, A Lipshtat, A Moter, A Novick, AE Merode van, AE Merode van, AE Tsong, B Muller-Hill, B Slutsky, BB Magee, BE Laue, BF Brehm-Stecher, BJ Haijema, C Hadden, C Wiuff, CM Hull, CM Hull, CM Southward, CY Lan, D Angeli, D Dubnau, D Dubnau, D Dubnau, D Kidane, D Sinderen van, D Sinderen van, DB Kearns, DC Dooley, DH Dean, DR Soll, E Korobkova, E Kussell, EH Rikkerink, EJ Stewart, EM Ozbudak, EM Ozbudak, ER Sumner, EW Nester, F Jacob, F Joux, F Ortega, F Russo-Marie, FH Cahn, FH Kasten, FJ Isaacs, G Huang, G Nebe-von-Caron, GM Suel, GM Suel, H Kobayashi, H Maamar, H Makinoshima, H Steinmoen, H Steinmoen, HB Fraser, HM Davey, I Golding, I Golding, I Hautefort, IR Henderson, J Casadesus, J Hahn, J Hahn, J Hasty, J Hasty, J Holtzendorff, J Kreth, J Monod, J Vidal-Mas, J Vives-Rego, J Zieg, JD Chung, JD Chung, JD Chung, JE Ferrell Jr, JE Ferrell Jr, JE Gonzalez-Pastor, JE Lisman, JM Abraham, JM Anderson, JM Pedraza, JR Glynn Jr, JW Veening, K Lewis, KA Susanna, KP Lemon, KZ Abshire, L Cai, LF Greer III, LW Hamoen, LW Hamoen, M Acar, M Albano, M Albano, M Albano, M Cohn, M Cohn, M Lange, M Laurent, M Leisner, M Santillán, M Thattai, M Woude van der, MB Elowitz, MB Elowitz, MG Miller, MJ Hoek van, MR Barer, N Chantratita, N Friedman, N Rosenfeld, N Yildirim, N Yildirim, NC Shaner, NC Shaner, NE Kramer, NQ Balaban, P Viswanathan, PS Swain, R Amann, R Carballido-Lopez, R Thomas, R Thomas, RA Daniel, RE Zordan, RI Amann, RJ Bennett, RM Morgan-Kiss, RN Singh, RN Singh, RP Burchard, RP Haugland, RY Tsien, S Guiral, S Hooshangi, S Stibitz, SB Williams, SE Finkel, SR Biggar, SR Lockhart, SR Lockhart, SV Avery, T Hornbaek, T Nishino, T Tian, T Tolker-Nielsen, TF Meyer, TS Gardner, TT Hoa, V Sentchilo, V Sentchilo, WK Smits, WK Smits, WK Smits   +159 more
core   +3 more sources