Results 151 to 160 of about 1,815,617 (316)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

TEAD-independent mechanisms of YAP function in cardiomyocyte cell cycle reentry. [PDF]

Life Sci Alliance
Xie B, Steimle J, Deshmukh V, Liu L, Tsai CR, Heallen TR, Paltzer W, Morikawa Y, Meng F, Wang J, Martin JF.   +10 more
europepmc   +1 more source

MAT2A Knockdown Enhances Recombinant Protein Expression in Transgenic CHO Cells Through Regulation of Cell Cycle [PDF]

Yan‐Ping Gao, Jiang‐Tao Lu, Huijie Zhang, Zhao‐Ming Cui, Guilian Yang, Xi Zhang, Wen Wang, Le‐Le Qiu, Xiao‐Yin Wang, Tianyun Wang, Yan‐Long Jia   +10 more
openalex   +1 more source

The Cell Cycle [PDF]

Science, 1989
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Esomeprazole inhibits proliferation of scleroderma fibroblasts via cell cycle regulation. [PDF]

Front Pharmacol
Khan MA, Koniyan S, Ahir M, Jegga AG, Mayes MD, Gius D, Leung J, Bonnen MD, Montesi SB, Ghebre YT.   +9 more
europepmc   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression. [PDF]

J Cell Sci
Nielsen JC, Benito-Jardon M, Christo Petrela N, Diring J, Bellamy S, Treisman R.   +5 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast. [PDF]

J Vis Exp
Stewart MG, Scheel TC, Abouelghar AA, Hoppe SE, Miller MP.   +4 more
europepmc   +1 more source