Results 181 to 190 of about 1,815,617 (316)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Activation of a FOXO3-induced cell cycle arrest regulates ferroptosis. [PDF]

Cell Death Discov
Huang H, van Sligtenhorst M, Smits AMM, Gulersonmez C, Stigter E, Dansen TB, Burgering BMT.   +6 more
europepmc   +1 more source

Editorial: Non-cell Cycle Functions of Cell Cycle Regulators

Frontiers in Cell and Developmental Biology, 2019
Song-Tao Liu, Gordon K. Chan, Weimin Li
openaire   +3 more sources

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Coupling of stemness maintenance with cell cycle control in stem cells. [PDF]

Front Cell Dev Biol
Huang X, Wang Y, Li Q, Li X, Wang C.
europepmc   +1 more source

Cell cycle proteins in benign laryngeal lesions

, 2008
Kamal Morshed, Danuta Skomra, Elżbieta Korobowicz, Marcin Szymański, Małgorzata Polz‐Dacewicz, Agnieszka Wawrzecka, Dorota Polz, Agata Smoleń   +7 more
openalex   +1 more source

Ctp1 Is a Cell-Cycle-Regulated Protein that Functions with Mre11 Complex to Control Double-Strand Break Repair by Homologous Recombination [PDF]

, 2007
Oliver Limbo, Charly Chahwan, Yoshiki Yamada, Robertus A.M. de Bruin, Curt Wittenberg, Paul Russell   +5 more
openalex   +1 more source

Cell Cycle Control.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 1998
openaire   +3 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Bioinformatics review of alcohol exposed neuronal stem cells and transcription factor consensus sequences in cell cycle progression genes.

, 2017
Mason Winkie, Bruce Anthony
openalex   +2 more sources