Results 131 to 140 of about 812,761 (308)
The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells
Cell Division, 2019 Background Cell cycle regulation is a complex system consisting of growth-promoting and growth-restricting mechanisms, whose coordinated activity is vital for proper division and propagation.
Ruth Viner-Breuer +3 more
doaj +1 more source
Centrosome-Dependent Bypass of the DNA Damage Checkpoint by the Polo Kinase Cdc5
Cell Reports, 2016 Cell-cycle checkpoints are essential feedback mechanisms that promote genome integrity. However, in the face of unrepairable DNA lesions, bypass mechanisms can suppress checkpoint activity and allow cells to resume proliferation. The molecular mechanisms
Hery Ratsima +3 more
doaj +1 more source
Cell cycle checkpoints: methods and protocols
European Journal of Histochemistry, 2012 As it is well known at the end of each cell cycle step there are checkpoints to verify that DNA duplication and segregation (among other events) met every requirements before the cell is allowed to proceed to the next step. Multiple signaling molecules, notably cyclins and the cyclin-dependent kinases (CDKs), play major roles in the cell cycle ...
openaire +3 more sources
FEBS Open Bio, EarlyView.Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy +14 more
wiley +1 more source
FEBS Open Bio, EarlyView.The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik +3 more
wiley +1 more source
Nature Communications, 2018 Checkpoint kinases control cell cycle progression via the regulation of many key regulators. Here the authors demonstrate how HDAC1 and HDAC2 modulate checkpoint kinase signalling via the suppression of PR130, a regulatory subunit of the trimeric serine ...
Anja Göder +10 more
doaj +1 more source
Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice.
Genes & Development, 2000 The recent discovery of checkpoint kinases has suggested the conservation of checkpoint mechanisms between yeast and mammals. In yeast, the protein kinase Chk1 is thought to mediate signaling associated with the DNA damage checkpoint of the cell cycle ...
H. Takai +9 more
semanticscholar +1 more source
Role of RPA Phosphorylation in the ATR-Dependent G2 Cell Cycle Checkpoint. [PDF]
Genes (Basel), 2023 Liu S, Byrne BM, Byrne TN, Oakley GG.
europepmc +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Reticulons bind sphingolipids to activate the endoplasmic reticulum cell cycle checkpoint, the ER surveillance pathway. [PDF]
Cell Rep, 2023 Piña F, Yan B, Hu J, Niwa M.
europepmc +1 more source