Results 131 to 140 of about 775,653 (341)

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

Ki-67 contributes to normal cell cycle progression and inactive X heterochromatin in p21 checkpoint-proficient human cells [PDF]

, 2017
Xiaoming Sun, Aizhan Bizhanova, Timothy D. Matheson, Yukun He, Lihua Julie Zhu, Paul D. Kaufman   +5 more
openalex   +1 more source

Prevalent and dynamic binding of the cell cycle checkpoint kinase Rad53 to gene promoters. [PDF]

Elife, 2022
Sheu YJ, Kawaguchi RK, Gillis J, Stillman B.   +3 more
europepmc   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Transcriptional Profiling of the Cell Cycle Checkpoint Gene Krüppel-Like Factor 4 Reveals a Global Inhibitory Function in Macromolecular Biosynthesis

, 2006
Erika M. Whitney, Amr M. Ghaleb, Xinming Chen, AND VINCENT W. YANG   +3 more
openalex   +1 more source

Cell cycle checkpoint signaling involved in histone deacetylase inhibition and radiation-induced cell death [PDF]

, 2005
Ragnhild V. Nome, Åse Bratland, Gunhild Harman, Øystein Fodstad, Yvonne Andersson, Anne Hansen Ree   +5 more
openalex   +1 more source

Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls. [PDF]

G3 (Bethesda), 2023
Liu Q, Pillus L, Petty EL.
europepmc   +1 more source

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

The Maize Homologue of the Cell Cycle Checkpoint Protein MAD2 Reveals Kinetochore Substructure and Contrasting Mitotic and Meiotic Localization Patterns [PDF]

, 1999
Hong-Guo Yu, Michael G. Muszynski, R. Kelly Dawe   +2 more
openalex   +1 more source

Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses. [PDF]

Signal Transduct Target Ther, 2023
Sui L, Li L, Zhao Y, Zhao Y, Hao P, Guo X, Wang W, Wang G, Li C, Liu Q.   +9 more
europepmc   +1 more source