Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery [PDF]
Nature Communications, 2018 DNA damage induces checkpoints to ensure that damage is not transferred to the next generation, but the molecular pathways responsible for checkpoint recovery are not clear.
Hui-Ju Hsieh +11 more
doaj +5 more sources
Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis. [PDF]
NPJ Syst Biol Appl, 2021 Abstract Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 activities than cancer cells without these mutations.
Jung Y +4 more
europepmc +6 more sources
DNA damage checkpoints balance a tradeoff between diploid- and polyploid-derived arrest failures [PDF]
Cell ReportsSummary: The DNA damage checkpoint system ensures genomic integrity by preventing the division of damaged cells, primarily through the G1/S and G2/M checkpoints. How these checkpoints collectively minimize error remains unclear.
Kotaro Fujimaki +2 more
doaj +2 more sources
RAD18 activates the G2/M checkpoint through DNA damage signaling to maintain genome integrity after ionizing radiation exposure. [PDF]
PLoS ONE, 2015 The ubiquitin ligase RAD18 is involved in post replication repair pathways via its recruitment to stalled replication forks, and its role in the ubiquitylation of proliferating cell nuclear antigen (PCNA).
Megumi Sasatani +11 more
doaj +4 more sources
PLK1 or WEE1 inhibition targets homologous recombination repair proficiency in BRCA1/2 wild-type high-grade serous ovarian cancer [PDF]
Cell Death and DiseaseHigh-grade serous ovarian cancer (HGSOC) is a poor prognostic disease, especially in BRCA1/2 wild-type (BRCA-WT) patients with homologous recombination (HR) proficiency.
Qian Xi +16 more
doaj +2 more sources
DNA damage checkpoint execution and the rules of its disengagement
Frontiers in Cell and Developmental Biology, 2022 Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation or ...
Candice Qiu Xia Yam +4 more
doaj +1 more source
ZGRF1 promotes end resection of DNA homologous recombination via forming complex with BRCA1/EXO1
Cell Death Discovery, 2021 To maintain genomic stability, the mammalian cells has evolved a coordinated response to DNA damage, including activation of DNA repair and cell cycle checkpoint processes.
Shuang Yan +9 more
doaj +1 more source
Genes & Development, 2022 The PBRM1 subunit of the PBAF (SWI/SNF) chromatin remodeling complex is mutated in ∼40% of clear cell renal cancers. PBRM1 loss has been implicated in responses to immunotherapy in renal cancer, but the mechanism is unclear. DNA damage-induced inflammatory signaling is an important factor determining immunotherapy response.
Hugang Feng +6 more
openaire +3 more sources
Regulation of Saccharomyces Rad53 Checkpoint Kinase during Adaptation from DNA Damage–Induced G2/M Arrest [PDF]
Molecular Cell, 2001 Saccharomyces cells with one unrepaired double-strand break (DSB) adapt after checkpoint-mediated G2/M arrest. Adaptation is accompanied by loss of Rad53p checkpoint kinase activity and Chk1p phosphorylation. Rad53p kinase remains elevated in yku70delta and cdc5-ad cells that fail to adapt.
A. Pellicioli +4 more
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2020 In zygotes, the capacity of G2/M checkpoint and DNA repair mechanisms to respond to DNA damage varies depending on different external stressors. In our previous studies, we found that mild oxidative stress induced a G2/M phase delay in mouse zygotes ...
Pei He +10 more
doaj +1 more source