Results 31 to 40 of about 57,844 (267)

RAD6-RAD18-RAD5-pathway-dependent tolerance to chronic low-dose ultraviolet light [PDF]

, 2009
In nature, organisms are exposed to chronic low- dose ultraviolet light ( CLUV) as opposed to the acute high doses common to laboratory experiments. Analysis of the cellular response to acute high-dose exposure has delineated the importance of direct DNA
Carr, Antony M, Hishida, T, Iwasaki, H, Kubota, Y   +3 more
core   +1 more source

The Protein Kinase Cδ Catalytic Fragment Is Critical for Maintenance of the G2/M DNA Damage Checkpoint [PDF]

Journal of Biological Chemistry, 2010
Protein kinase Cdelta (PKCdelta) is an essential component of the intrinsic apoptotic program. Following DNA damage, such as exposure to UV radiation, PKCdelta is cleaved in a caspase-dependent manner, generating a constitutively active catalytic fragment (PKCdelta-cat), which is necessary and sufficient for keratinocyte apoptosis.
Edward L, LaGory, Leonid A, Sitailo, Mitchell F, Denning   +2 more
openaire   +2 more sources

Impairment of RAD17 Functions by miR-506-3p as a Novel Synthetic Lethal Approach Targeting DNA Repair Pathways in Ovarian Cancer

Frontiers in Oncology, 2022
Epithelial ovarian cancer (EOC) remains the most lethal gynecological cancer and development of chemo-resistance is a major factor in disease relapse.
Marina Bagnoli, Roberta Nicoletti, Monica Valitutti, Andrea Rizzo, Alessandra Napoli, Rafaela Montalvão De Azevedo, Antonella Tomassetti, Delia Mezzanzanica   +7 more
doaj   +1 more source

Targeting ATM pathway for therapeutic intervention in cancer [PDF]

, 2012
The Ataxia Telangiectasia Mutated gene encodes the ATM protein, a key element in the DNA damage response (DDR) signalling pathway responsible for maintaining genomic integrity within the cell.
Chakarov, Stoyan, Khalil, Hilal S., Lane, David P., Tummala, Hemanth, Zhelev, Nikolai   +4 more
core   +3 more sources

Oxidative stress-induced DNA damage of mouse zygotes triggers G2/M checkpoint and phosphorylates Cdc25 and Cdc2 [PDF]

Cell Stress and Chaperones, 2016
In vitro fertilized (IVF) embryos show both cell cycle and developmental arrest. We previously showed oxidative damage activates the ATM → Chk1 → Cdc25B/Cdc25C cascade to mediate G2/M cell cycle arrest for repair of hydrogen peroxide (H2O2)-induced oxidative damage in sperm.
Yuting, Zhang, Diting, Qian, Zhiling, Li, Yue, Huang, Que, Wu, Gaizhen, Ru, Man, Chen, Bin, Wang   +7 more
openaire   +2 more sources

Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm. [PDF]

PLoS ONE, 2013
Human sperm cryopreservation for assisted reproduction is compromised by ROS-induced sperm cryodamage. Our previous model study in which mouse sperm were treated with H₂O₂ to simulate sperm DNA-damage caused by cryopreservation-induced ROS have ...
Bin Wang, Zhiling Li, Chao Wang, Man Chen, Jianfeng Xiao, Xiaoyan Wu, Wanfen Xiao, Yu Song, Xiaoyan Wang   +8 more
doaj   +1 more source

The Arabidopsis thaliana checkpoint kinase WEE1 protects against premature vascular differentiation during replication stress [PDF]

, 2011
A sessile lifestyle forces plants to respond promptly to factors that affect their genomic integrity. Therefore, plants have developed checkpoint mechanisms to arrest cell cycle progression upon the occurrence of DNA stress, allowing the DNA to be ...
Cools, Toon, Iantcheva, Anelia, Weimer, Annika K, Boens, Shannah, Takahashi, Naoki, Maes, Sara, Van Den Daele, Hilde, Van Isterdael, Gert, Schnittger, Arp, De Veylder, Lieven   +9 more
core   +2 more sources

Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells [PDF]

, 2020
The authors have withdrawn their manuscript due to authorship disputes. Therefore, they do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author.
Yongwoon Jung, Pavel Kraikivski
openaire   +1 more source

DNA resection in eukaryotes: deciding how to fix the break [PDF]

, 2010
DNA double-strand breaks are repaired by different mechanisms, including homologous recombination and nonhomologous end-joining. DNA-end resection, the first step in recombination, is a key step that contributes to the choice of DSB repair.
A Aguilera, A Jazayeri, A Jazayeri, A Penkner, AA Sartori, AH McKee, AV Nimonkar, B Gu, BB Hopkins, BM Lengsfeld, BO Krogh, C Uanschou, C Zierhut, CF Cheok, CJ Lord, D Mantiero, D Nakada, DA Bressan, DO Warmerdam, E Baroni, EP Mimitou, F Lazzaro, G Chinnadurai, G Ira, G Wu, I Morin, J Buis, J Falck, JC Harrison, JH Barlow, JH Kim, JP Duxin, K Lee, K Shimada, KM Trujillo, L Chen, L Chen, L Maringele, L Zheng, M Clerici, M Clerici, M Grenon, M Lisby, M McVey, MF Lavin, MH Yun, MJ Neale, MR Lieber, O Limbo, P Huertas, P Huertas, Pablo Huertas, PL Chen, PT Tran, R Linding, R Waltes, RR Khakhar, RS Williams, S Gravel, S Liao, S Moreau, S Prinz, SH Bae, SK Amundsen, T Usui, TH Stracker, TT Paull, WS Dynan, X Yu, X Yu, Y Akamatsu, Y Aylon, Y Zhang, Z Horejsí, Z Zhu   +74 more
core   +1 more source

Impacts of prolonged exposure to low concentration of titanium dioxide nanoparticles on cell cycle control and DNA repair

European Journal of Biological Research, 2022
Although the toxicological profile of titanium dioxide nanoparticles is not fully illuminated, large quantities of titanium dioxide nanoparticles (TiO2NPs) are now produced.
Nada El Zahed, Andreas Kakarougkas
doaj