The G2/M DNA damage checkpoint inhibits mitosis through Tyr15 phosphorylation of p34cdc2 in Aspergillus nidulans [PDF]
The EMBO Journal, 1997 It is possible to cause G2 arrest in Aspergillus nidulans by inactivating either p34cdc2 or NIMA. We therefore investigated the negative control of these two mitosis-promoting kinases after DNA damage. DNA damage caused rapid Tyr15 phosphorylation of p34cdc2 and transient cell cycle arrest but had little effect on the activity of NIMA.
X S, Ye +3 more
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Pathways for Genome Integrity in G2 Phase of the Cell Cycle
Biomolecules, 2012 The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen +2 more
doaj +1 more source
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing [PDF]
, 2001 Checkpoints maintain order and fidelity in the cell cycle by blocking late-occurring events when earlier events are improperly executed. Here we describe evidence for the participation of Chk1 in an intra-S phase checkpoint in mammalian cells.
Feijoo, Carmen +6 more
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Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
DNA damage stress: Cui prodest? [PDF]
, 2019 DNA is an entity shielded by mechanisms that maintain genomic stability and are essential for living cells; however, DNA is constantly subject to assaults from the environment throughout the cellular life span, making the genome susceptible to mutation ...
Cialfi, Samantha +5 more
core +1 more source
Possible attenuation of the G2 DNA damage cell cycle checkpoint in HeLa cells by extremely low frequency (ELF) electromagnetic fields [PDF]
, 2002 BACKGROUND: The issue remains unresolved as to whether low frequency magnetic fields can affect cell behaviour, with the possibility that they may be in part responsible for the increased incidence of leukaemia in parts of the population exposed to ...
Harris, Paul A. +3 more
core +3 more sources
Drosophila FMRP participates in the DNA damage response by regulating G2/M cell cycle checkpoint and apoptosis [PDF]
Human Molecular Genetics, 2012 Fragile X syndrome, the most common form of inherited mental retardation, is caused by the loss of the fragile X mental retardation protein (FMRP). FMRP is a ubiquitously expressed, multi-domain RNA-binding protein, but its in vivo function remains poorly understood.
Wei, Liu +3 more
openaire +2 more sources
Cyclin-Dependent Kinase 2–Dependent Phosphorylation of ATRIP Regulates the G2-M Checkpoint Response to DNA Damage [PDF]
Cancer Research, 2007 AbstractThe ATR-ATRIP kinase complex regulates cellular responses to DNA damage and replication stress. Mass spectrometry was used to identify phosphorylation sites on ATR and ATRIP to understand how the kinase complex is regulated by post-translational modifications.
Jeremy S, Myers +4 more
openaire +2 more sources
Ddc2 mediates Mec1 activation through a Ddc1- or Dpb11-independent mechanism.
PLoS Genetics, 2014 The protein kinase Mec1 (ATR ortholog) and its partner Ddc2 (ATRIP ortholog) play a key role in DNA damage checkpoint responses in budding yeast. Previous studies have established the model in which Ddc1, a subunit of the checkpoint clamp, and Dpb11 ...
Amitava Bandhu +4 more
doaj +1 more source
WEE1 kinase is a therapeutic vulnerability in CIC-DUX4 undifferentiated sarcoma
JCI Insight, 2022 CIC-DUX4 rearrangements define an aggressive and chemotherapy-insensitive subset of undifferentiated sarcomas. The CIC-DUX4 fusion drives oncogenesis through direct transcriptional upregulation of cell cycle and DNA replication genes.
Rovingaile Kriska M. Ponce +4 more
doaj +1 more source