Results 41 to 50 of about 57,844 (267)

The G2 checkpoint activated by DNA damage does not prevent genome instability in plant cells [PDF]

, 2006
Root growth, G2 length, and the frequency of aberrant mitoses and apoptotic nuclei were recorded after a single X-ray irradiation, ranging from 2.5 to 40 Gy, in Allium cepa L. root meristematic cells.
Carballo, Jesús A, de la Torre, Consuelo, Pincheira, Juana   +2 more
core   +4 more sources

NPRL2 sensitizes human non-small cell lung cancer (NSCLC) cells to cisplatin treatment by regulating key components in the DNA repair pathway. [PDF]

PLoS ONE, 2010
NPRL2, one of the tumor suppressor genes residing in a 120-kb homozygous deletion region of human chromosome band 3p21.3, has a high degree of amino acid sequence homology with the nitrogen permease regulator 2 (NPR2) yeast gene, and mutations of NPRL2 ...
Gitanjali Jayachandran, Kentaro Ueda, Bingbing Wang, Jack A Roth, Lin Ji   +4 more
doaj   +1 more source

RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene [PDF]

Oncogene, 2006
As alterations in retinoblastoma (RB)/E2F pathway are commonly found in human cancers, the molecular mechanism underlying cell cycle deregulation caused by the mutations in the RB/E2F pathway needs to be investigated extensively. Compared with good understanding of RB/E2F functions in G1-S cell cycle progression, it is not fully understood how an ...
T, Eguchi, T, Takaki, H, Itadani, H, Kotani   +3 more
openaire   +2 more sources

Increased chromosomal radiosensitivity in asymptomatic carriers of a heterozygous BRCA1 mutation [PDF]

, 2016
Background: Breast cancer risk increases drastically in individuals carrying a germline BRCA1 mutation. The exposure to ionizing radiation for diagnostic or therapeutic purposes of BRCA1 mutation carriers is counterintuitive, since BRCA1 is active in the
A Pijpe, A Vral, Anne Vral, Annelot Baert, B Ernestos, Bruce Poppe, D Goldfrank, E Febrer, EKJ Pauwels, EM John, F Cardinale, FJ Couch, Fransiska Malfait, G Sioftanos, GE Pantelias, Gianpaolo Perletti, GJ Heyes, H Nikjoo, I Cousineau, IM Obdeijn, J Barwell, J Depuydt, J Gronwald, J Lecarpentier, JC Drooger, JC Théry, Jenneke van den Ende, JL Bernheim, JM Hair, Julie Depuydt, K Claes, K Claes, K Claes, K Leeneer De, Kathleen B. M. Claes, Katrien Storm, KE Rieger, Kim De Leeneer, KW Caestecker, L Perrin-Vidoz, L Salmena, M Frankenberg-Schwager, M Sedic, ME Dextraze, MS Sasaki, N Andrieu, N Foray, N Li, O Anczuków, O Popanda, P Pfeiffer, P Willems, R Roy, RI Yarden, RJ Linger, S Gutiérrez-Enríquez, S Pathania, SA Narod, Sylvia De Nobele, T Vaclová, TA Buchholz, Tim Van Damme, Tom Van Maerken, U Hagen, V Giannakeas, WD Foulkes, Z Guo, Z Kote-Jarai   +67 more
core   +4 more sources

The Tumor Suppressor MIG6 Controls Mitotic Progression and the G2/M DNA Damage Checkpoint by Stabilizing the WEE1 Kinase [PDF]

Cell Reports, 2018
MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as an integral component of the cell cycle machinery. We found that depletion of MIG6 causes accelerated entry into and delayed exit from mitosis.
Sasaki M, Terabayashi T, Weiss SM, Ferby I   +3 more
openaire   +4 more sources

Phosphorylation-dependent assembly and coordination of the DNA damage checkpoint apparatus by Rad4TopBP1 [PDF]

, 2013
The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator.
Alcasabas, Antony M. Carr, Antony W. Oliver, Boos, Cescutti, Christopher P. Wardlaw, Du, Du, Du, Esashi, Fenech, Fukuura, Furuya, Garcia, Gong, Jing-Yi Ren, Kilkenny, Kumagai, Kumagai, Kumagai, Laurence H. Pearl, Lee, Lee, Li-Lin Du, Lin, Mathieu Rappas, Matthew Day, Meng Qu, Qu, Rappas, Rothbauer, Saka, Shiozaki, Smits, Stucki, Takeishi, Tanaka, Taylor, Valerie Garcia, Williams, Willson   +40 more
core   +1 more source

Cdk5 Activator-binding Protein C53 Regulates Apoptosis Induced by Genotoxic Stress via Modulating the G2/M DNA Damage Checkpoint [PDF]

Journal of Biological Chemistry, 2005
In response to DNA damage, the cellular decision of life versus death involves an intricate network of multiple factors that play critical roles in regulation of DNA repair, cell cycle, and cell death. DNA damage checkpoint proteins are crucial for maintaining DNA integrity and normal cellular functions, but they may also reduce the effectiveness of ...
Hai, Jiang, Shouqing, Luo, Honglin, Li
openaire   +2 more sources

Dicer prevents genome instability in response to replication stress [PDF]

, 2019
Dicer, an endoribonuclease best-known for its role in microRNA biogenesis and RNA interference pathway, has been shown to play a role in the DNA damage response and repair of double-stranded DNA breaks (DSBs) in mammalian cells.
Barra, Viviana, Bordignon, Benoit, Coquelle, Arnaud, Egger, Tom, Fragkos, Michalis, Lemacon, Delphine, Naim, Valeria   +6 more
core   +2 more sources

The cohesin complex is required for the DNA damage‐induced G2/M checkpoint in mammalian cells

The EMBO Journal, 2009
Cohesin complexes mediate sister chromatid cohesion. Cohesin also becomes enriched at DNA double-strand break sites and facilitates recombinational DNA repair. Here, we report that cohesin is essential for the DNA damage-induced G2/M checkpoint. In contrast to cohesin's role in DNA repair, the checkpoint function of cohesin is independent of its ...
Watrin, Erwan, Peters, Jan-Michael
openaire   +3 more sources

Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage [PDF]

Nucleic Acids Research, 2012
Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions. dCK is activated in response to DNA damage; however, how it functions in the DNA damage response is largely unknown.
Yang, Chunying, Lee, Michael, Hao, Jianwei, Cui, Xiaoli, Guo, Xiaojing, Smal, Caroline, Bontemps, Francoise, Ma, Shumei, Liu, Xiaodong, Engler, David, Parker, William B., Xu, Bo   +11 more
openaire   +3 more sources