Results 181 to 190 of about 775,653 (341)

Orchestration of DNA Damage Checkpoint Dynamics across the Human Cell Cycle.

Cell Systems, 2017
H. Chao, Cere E. Poovey, Ashley A. Privette, Gavin D. Grant, Hui Yan Chao, J. Cook, J. Purvis   +6 more
semanticscholar   +1 more source

Centromere Protein I, a Cell Cycle Checkpoint Gene, Accelerates Tumor Progression via the Hippo Pathway and Mediates Immune Escape in Hepatocellular Carcinoma. [PDF]

J Clin Transl Hepatol
He R, Xu Y, Zhang P, Yu L, Ma J, Cui Y.
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Data from PLK1 Induces Chromosomal Instability and Overrides Cell-Cycle Checkpoints to Drive Tumorigenesis

, 2023
Lilia Gheghiani, Lei Wang, Youwei Zhang, Xavier T.R. Moore, Jinglei Zhang, Steven C. Smith, Yijun Tian, Liang Wang, Kristi Turner, Colleen Jackson‐Cook, Nitai D. Mukhopadhyay, Zheng Fu   +11 more
openalex   +1 more source

S1PR3 inhibition impairs cell cycle checkpoint via the AKT/WEE1 pathway in oral squamous cell carcinoma. [PDF]

J Transl Med
Zhou X, Liu J, Chen X, Zhou X, Xu B, Gan G, Chen F.   +6 more
europepmc   +1 more source

Interferon‐Driven Biomarkers and Synergistic Therapy for PRMT5 Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Triple‐negative breast cancer exhibits variable sensitivity to PRMT5 inhibition. Basal interferon signaling is identified as a key biomarker of response. PARP inhibition with olaparib induces IFN signaling, sensitizing resistant TNBC cells to PRMT5 inhibitors.
Ziwen Zhang, Sheyu Zhang, Lu Guo, Yichun Pan, Juan Huang, Yishuai Ji, Jiaqi Tao, Yong Wei, Xiaojia Wang, Qin Wu   +9 more
wiley   +1 more source

Cdc123 and Checkpoint Forkhead Associated with RING Proteins Control the Cell Cycle by Controlling eIF2γ Abundance

, 2004
Paweł Bieganowski, Kara Shilinski, Philip N. Tsichlis, Charles Brenner   +3 more
openalex   +1 more source

Development of cell-cycle checkpoint therapy for solid tumors.

Japanese Journal of Clinical Oncology, 2015
K. Tamura
semanticscholar   +1 more source

Tumor‐Derived CDC37 Inhibits Antigen Cross‐Presentation in Dendritic Cells and Impairs Anti‐Tumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Extracellular vesicle (EV)‐packaged CDC37 are released from TMBhiCTLlo breast cancer cells with high CDC37 expression, and internalized into endo/phagosomes of dendritic cells (DCs). Within these compartments, CDC37 locked HSP90–antigen complex, preventing antigen release into the cytosol.
Ruxin Wang, Yunyi Zhang, Xiangyu Meng, Jianli Zhao, Yue Xing, Qian Ouyang, Ning Zhang, Huiping Chen, Nanyan Miao, Erwei Song, Di Huang   +10 more
wiley   +1 more source

Author Correction: TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway. [PDF]

Sci Rep
Arroyo M, Fernández-Mimbrera MA, Gollini E, Esteve-Codina A, Sánchez A, Marchal JA.   +5 more
europepmc   +1 more source