Results 201 to 210 of about 775,653 (341)

Cell cycle checkpoint revolution: targeted therapies in the fight against malignant tumors. [PDF]

Front Pharmacol
Song G, Liu J, Tang X, Zhong J, Zeng Y, Zhang X, Zhou J, Zhou J, Cao L, Zhang Q, Li Y.   +10 more
europepmc   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

Context-Dependent Cell Cycle Checkpoint Abrogation by a Novel Kinase Inhibitor

, 2010
Andrew J. Massey, Jenifer Borgognoni, Carol Bentley, Nicolas Foloppe, Andreá Fiumana, Lee Walmsley   +5 more
openalex   +2 more sources

IKKα Shields 14-3-3σ, a G2/M Cell Cycle Checkpoint Gene, from Hypermethylation, Preventing Its Silencing [PDF]

, 2007
Feng Zhu, Xiaojun Xia, Bigang Liu, Jianjun Shen, Yuhui Hu, Maria D. Person, Yinling Hu   +6 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Activation of p38 MAP kinase by DNA double‐strand breaks in V(D)J recombination induces a G2/M cell cycle checkpoint [PDF]

, 2006
Gustavo Pedraza‐Alva, Miroslav Koulnis, Colette Charland, Tina M. Thornton, James L. Clements, Mark S. Schlissel, Mercedes Rincón   +6 more
openalex   +1 more source

The Potential for Targeting G₂/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy. [PDF]

Cancers (Basel)
Melia E, Parsons JL.
europepmc   +1 more source

Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells. [PDF]

Am J Pathol, 2021
De La Cena KOC, Ho RX, Amraei R, Woolf N, Tashjian JY, Zhao Q, Richards S, Walker J, Huang J, Chitalia VC, Rahimi N.   +10 more
europepmc   +1 more source

CYP4X1/sEH‐Dependent Endocannabinoid Metabolism Drives Fibroblast‐Mediated Immunosuppression to Limit Immunotherapy in Colon Cancer

Advanced Science, EarlyView.
A proposed mechanism to explain the role of CYP4X1/sEH‐14,15‐EET‐EA system in colon cancer immune escape. 14,15‐EET‐EA, 14,15‐epoxyeicosatrienoic acid‐ethanolamide; sEH, soluble epoxide hydrolase; CYP4X1, cytochrome P450 4X1; GPR119, G‐protein coupled receptor 119; EGFR, epidermal growth factor receptor; Gs, Gαs subunit; cAMP, cyclic adenosine ...
Min Mo, Xuewei Chen, Yanzhuo Liu, Chenlong Wang, Xuehan Chen, Nan Zhang, Nan He, Ying Li, Jingyi Wang, Honglei Chen, Jing Yang   +10 more
wiley   +1 more source

Regulation of cell cycle checkpoint kinase WEE1 by miR-195 in malignant melanoma

Oncogene, 2013
Animesh Bhattacharya, U. Schmitz, O. Wolkenhauer, Madeleine Schönherr, Yvonne Raatz, M. Kunz   +5 more
semanticscholar   +1 more source