Results 231 to 240 of about 775,653 (341)

A phase II study of the cell cycle checkpoint kinases 1 and 2 (CHK1/2) inhibitor (LY2606368; prexasertib) in sporadic triple negative breast cancer (TNBC) [PDF]

, 2016
Fatima Karzai, Alexandra S. Zimmer, S Lipkowitz, Christina M. Annunziata, B. Parker, Nicole Houston, Irene Ekwede, Elise C. Kohn, J.-M. Lee   +8 more
openalex   +1 more source

Cell cycle proteins as promising targets in cancer therapy

Nature Reviews. Cancer, 2017
T. Otto, P. Sicinski
semanticscholar   +1 more source

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, EarlyView.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

Cell Cycle Checkpoints and Cancer [PDF]

, 2002
Jiří Bártek
openalex   +1 more source

GADD45 induction of a G2/M cell cycle checkpoint.

Proceedings of the National Academy of Sciences of the United States of America, 1999
X. W. Wang, Q. Zhan, J. Coursen, Mohammed A. Khan, H. U. Kontny, Yu Lijia, M. Hollander, P. O'Connor, A. Fornace, C. Harris   +9 more
semanticscholar   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

The Arabidopsis Cell Cycle Checkpoint Regulators TANMEI/ALT2 and ATR Mediate the Active Process of Aluminum-Dependent Root Growth Inhibition[C][W]

The Plant Cell, 2012
Cynthia D. Nezames, Caroline A. Sjogren, J. F. Barajas, P. Larsen   +3 more
semanticscholar   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Methotrexate increases expression of cell cycle checkpoint genes via JNK activation.

Arthritis & Rheumatism, 2012
Charles F. Spurlock, J. Tossberg, H. Fuchs, N. Olsen, T. Aune   +4 more
semanticscholar   +1 more source